Apparatus and method for quantification of tissue hydration using diffuse reflectance spectroscopy
First Claim
1. An apparatus for estimating a tissue property non-destructively, based on spectral measurements, comprising:
- means for measuring a spectrum at a selected tissue site on a subject;
an estimation model developed from a calibration set of exemplary samples and independent measurements; and
an analyzer, wherein processing is applied to said spectrum and said model subsequently applied to determine an estimate of said tissue property.
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Abstract
An apparatus and method for non-destructively estimating a tissue property, such as hydration, of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, an estimation model developed from an exemplary set of measurements is applied to predict the tissue hydration for the sample. The method of tissue hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. Tissue hydration measurement is therefore suitable for further spectral analysis and quantification of biological and chemical compounds, such as analytes.
223 Citations
48 Claims
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1. An apparatus for estimating a tissue property non-destructively, based on spectral measurements, comprising:
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means for measuring a spectrum at a selected tissue site on a subject;
an estimation model developed from a calibration set of exemplary samples and independent measurements; and
an analyzer, wherein processing is applied to said spectrum and said model subsequently applied to determine an estimate of said tissue property. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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Specification