Implantable artificial organ devices

• US 20030060695A1
• Filed: 07/30/2002
• Published: 03/27/2003
• Est. Priority Date: 03/07/2001
• Status: Abandoned Application

• Current Assignee: Biomed Solutions, LLC
• Original Assignee: Biomed Solutions, LLC
• Inventors: Connelly, Patrick R.
• Application Number:
  US10/208,288
• Publication Number:
  US 20030060695A1
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150274 Manufacture or production processes or steps for blood sampling devices
• CPC Class Codes: A61B 5/15087 short range, e.g. between console and disposable using implanted devices A61B5/150877
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/3689 by biological cells
• CPC Class Codes: A61M 1/38 : Removing constituents from donor blood and storing or returning remainder to body , e.g. for transfusion
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: G01N 15/10 : Investigating individual particles
• CPC Class Codes: G01N 15/1456 : without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
• CPC Class Codes: G01N 15/149 : specially adapted for sorting particles, e.g. by their size or optical properties
• CPC Class Codes: G01N 2015/1006 : for cytology

Abstract

An implantable apparatus for delivering a first therapeutic agent within a living biological organism. The apparatus is comprised of a first in vitro cell culture for producing a first therapeutic agent, an implantable pump for delivering the first therapeutic agent, a controller, and a power supply.

Claims

1. An implantable apparatus for delivering a first therapeutic agent within a living biological organism, wherein said apparatus is comprised of a first in vitro cell culture for producing said first therapeutic agent, an implantable pump for delivering said first therapeutic agent, a controller, a power supply, means for delivering power from said power supply to said controller, and means for delivering power from said power supply to said pump.

2. The implantable apparatus as recited in claim 1, wherein said implantable apparatus further comprises implantable means for supplying nutrient to said first in vitro cell culture.

3. The implantable apparatus as recited in claim 2, wherein said implantable means for supplying nutrient to said first in vitro cell culture comprises a nutrient tube.

4. The implantable apparatus as recited in claim 1, wherein said controller is a microprocessor controller.

5. The implantable apparatus as recited in claim 1, wherein said therapeutic agent is an endogenous therapeutic agent.

6. The implantable apparatus as recited in claim 1, further comprising a second in vitro cell culture for delivering a second therapeutic agent.

7. The implantable apparatus as recited in claim 1, further comprising an isolator assembly for isolating said first therapeutic agent.

8. The implantable apparatus as recited in claim 7, wherein said isolator assembly is comprised of a first isolator column, a second isolator column, a third isolator column, and a fourth isolator column.

9. The implantable apparatus as recited in claim 7, further comprising a reservoir assembly.

10. The implantable apparatus as recited in claim 9, wherein said reservoir assembly is comprised of a first reservoir bag.

11. The implantable apparatus as recited in claim 1, wherein said apparatus is implanted in the upper thoracic region of a living organism.

12. The implantable apparatus as recited in claim 11, wherein said apparatus is implanted in said thoracic region of said living organism lateral to a trachea.

13. The implantable apparatus as recited in claim 1, further comprising an implantable airflow sensor.

14. The implantable apparatus as recited in claim 13, further comprising means for connecting said implantable air flow sensor to said controller.

15. The implantable apparatus as recited in claim 1, further comprising an implantable compressor.

16. The implantable apparatus as recited in claim 14, further comprising an implantable compressor.

17. The implantable apparatus as recited in claim 16, further comprising a reservoir assembly.

18. The implantable apparatus as recited in claim 17, wherein said implantable compressor is comprised of means for withdrawing said first therapeutic agent from said reservoir assembly.

19. The implantable apparatus as recited in claim 1, further comprising a therapeutic agent feed tube.

20. The implantable apparatus as recited in claim 18, further comprising a therapeutic agent feed tube.

21. The implantable apparatus as recited in claim 20, wherein said implantable compressor is comprised of means for delivering said therapeutic agent into said therapeutic agent feed tube.

22. The implantable apparatus as recited in claim 1, further comprising a first implantable valve.

23. The implantable apparatus as recited in claim 21, further comprising a first implantable valve for controlling the flow of fluid into said compressor.

24. The implantable apparatus as recited in claim 23, further comprising a second implantable valve for controlling the flow of fluid out of said compressor.

25. The implantable apparatus as recited in claim 24, wherein said fluid is selected from the group consisting of gas, liquid, and mixtures thereof.

26. The implantable apparatus as recited in claim 25, wherein said gas is comprised of air.

27. The implantable apparatus as recited in claim 25, wherein said fluid is air.

28. The implantable apparatus as recited in claim 1, wherein said controller is comprised of a telemetric link.

29. The implantable apparatus as recited in claim 24, wherein each of said first implantable valve and said second implantable valve is a microvalve.

30. The implantable apparatus as recited in claim 1, wherein said pump is a micropump.

31. The implantable apparatus as recited in claim 30, wherein said micropump is an electroosmotic micropump.

32. The implantable apparatus as recited in claim 1, wherein said first therapeutic agent is antihistamine.

33. The implantable apparatus as recited in claim 1, wherein said first therapeutic agent is corticosteroid.

34. The implantable apparatus as recited in claim 1, wherein said first therapeutic agent is a statin.

35. The implantable apparatus as recited in claim 34, wherein said statin is selected from the group consisting of lovastatin, pravastatin, simvastatin, cerivastatin, fluvastatin, atorvastatin, mevastatin, and mixtures thereof.

36. The implantable apparatus as recited in claim 1, wherein said therapeutic agent is an HMG-CoA reductase inhibitor.

37. The implantable apparatus as recited in claim 1, wherein said therapeutic agent is an antibody.

38. The implantable apparatus as recited in claim 37, wherein said antibody is an antibody to the antigens causing multiple sclerosis.

39. The implantable apparatus as recited in claim 37, wherein said in vitro cell culture is comprised of hybridoma cells adapted to produce said antibody.

40. The implantable apparatus as recited in claim 1, wherein said therapeutic agent is a chemokine protein.

41. The implantable apparatus as recited in claim 1, wherein said therapeutic agent is a lipid metabolism transcription factor.