Method and device for detecting and quantifying biomolecules
First Claim
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1. A method of detecting and/or quantifying a first biomolecule (5, 8) present in a solution, having the following steps:
- a) binding of the first molecule (5, 8) to a second biomolecule (3, 7) which, at least in sections, possesses specific affinity to the first biomolecule (5, 8) and b) measuring of the electrical conductivity of the complex formed from the first (3, 7) and second biomolecules (5, 8), the second biomolecule (3, 7) forming a bridge between a first electrode (2a) and a second electrode (2b).
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Abstract
The invention relates to a method for detecting and quantifying a first biomolecule in solution (5, 8), comprising the following steps: a) binding of the first biomolecule (5, 8) to a second biomolecule (3, 7) which at least along segments thereof exhibits a specific affinity to a first biomolecule and b) determination of the electrical conductivity of the complex formed from the first (3, 7) and the second biomolecule (5, 8), whereby the second biomolecule (3, 7) forms a bridge between a first 2a and a second electrode 2b.
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Citations
37 Claims
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1. A method of detecting and/or quantifying a first biomolecule (5, 8) present in a solution, having the following steps:
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a) binding of the first molecule (5, 8) to a second biomolecule (3, 7) which, at least in sections, possesses specific affinity to the first biomolecule (5, 8) and b) measuring of the electrical conductivity of the complex formed from the first (3, 7) and second biomolecules (5, 8), the second biomolecule (3, 7) forming a bridge between a first electrode (2a) and a second electrode (2b). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A device for detecting and/or quantifying a first biomolecule (5, 8) present in a solution, wherein
aa) a first electrode (2a) and a second electrode (2b) are applied on an electrically insulating substrate (1), bb) bound at least to the first electrode (2a) by its one end (E1) is a second biomolecule (3, 7) which, at least in sections, possesses a specific affinity to the first biomolecule (5, 8), and wherein cc) the distance between the first electrode (2a) and the second electrode (2b) is chosen such that by binding the other end (E2) of the second biomolecule (3, 7) it is possible to produce a bridge between the first electrode (2a) and the second electrode (2b).
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