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Synthesis of spatially addressed molecular arrays

  • US 20030064398A1
  • Filed: 08/01/2002
  • Published: 04/03/2003
  • Est. Priority Date: 02/02/2000
  • Status: Active Grant
First Claim
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1. A method for forming a spatially addressable array of polymers immobilized on a solid support, comprising the steps of:

  • (i) contacting an array of single molecules with one or more detectably labelled monomers, under conditions that permit incorporation of a monomer onto a molecule of the array, wherein the labelled monomer comprises a removable blocking group that prevents further monomer incorporation occurring;

    (ii) removing non-incorporated monomers and detecing the label on the incorporated monomer;

    (iii) removing the blocking group and any separate label; and

    (iv) optionally repeating steps (i)-(iii) to form a single polymer of defined sequence;

    wherein the array has a surface density which allows each polymer to be individually resolved by optical microscopy.

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