Method and system for collecting and transmitting chemical information
First Claim
Patent Images
1. A system for detecting an analyte in a fluid comprising:
- a light source;
a sensor array, the sensor array comprising a supporting member comprising at least one cavity formed within the supporting member;
a particle, the particle positioned within the cavity, wherein the particle is configured to produce a signal when the particle interacts with the analyte during use; and
a detector, the detector being configured to detect the signal produced by the interaction of the analyte with the particle during use;
wherein the light source and detector are positioned such that light passes from the light source, to the particle, and onto the detector during use.
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Abstract
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.
161 Citations
415 Claims
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1. A system for detecting an analyte in a fluid comprising:
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a light source;
a sensor array, the sensor array comprising a supporting member comprising at least one cavity formed within the supporting member;
a particle, the particle positioned within the cavity, wherein the particle is configured to produce a signal when the particle interacts with the analyte during use; and
a detector, the detector being configured to detect the signal produced by the interaction of the analyte with the particle during use;
wherein the light source and detector are positioned such that light passes from the light source, to the particle, and onto the detector during use. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 156)
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82. The system of claim wherein the particle comprises a biopolymer coupled to a polymeric resin, and wherein the biopolymer undergoes a chemical reaction in the presence of the analyte to produce a signal, and wherein the chemical reaction comprises cleavage of the biopolymer by the analyze.
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94. A system for detecting an analyte in a fluid comprising:
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a light source;
a sensor array, the sensor array comprising;
a supporting member;
wherein a first cavity and a second cavity are formed within the supporting member;
a first particle positioned within the first cavity;
a second particle positioned within the second cavity, wherein the second particle comprises a reagent, wherein a portion of the reagent is removable from the second particle when contacted with a decoupling solution, and wherein the reagent is configured to modify the first particle, when the reagent is contacted with the first particle, such that the first particle will produce a signal when the first particle interacts with the analyte during use;
a first pump coupled to the supporting member, wherein the pump is configured to direct the fluid towards the first cavity;
a second pump coupled to the supporting member, wherein the second pump is configured to direct the decoupling solution towards the second cavity;
wherein a first channel is formed in the supporting member, the first channel coupling the first pump to the first cavity such that the fluid flows through the first channel to the first cavity during use, and wherein a second channel is formed in the supporting member, the second channel coupling the second cavity to the first cavity such that the decoupling solution flows from the second cavity through the second channel to the first cavity during use; and
a detector, the detector being configured to detect the signal produced by the interaction of the analyte with the particle during use;
wherein the light source and detector are positioned such that light passes from the light source, to the particle, and onto the detector during use. - View Dependent Claims (95, 96, 97, 98)
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99. A system for detecting an analyte in a fluid comprising:
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a light source;
a sensor array, the sensor array comprising at least one particle coupled to the sensor array, wherein the particle is configured to produce a signal when the particle interacts with the analyte; and
a detector configured to detect the signal produced by the interaction of the analyte with the particle;
wherein the light source and detector are positioned such that light passes from the light source, to the particle, and onto the detector during use.
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100. A sensor array for detecting an analyte in a fluid comprising:
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a supporting member;
wherein at least one cavity is formed within the supporting member;
a particle positioned within the cavity, wherein the particle is configured to produce a signal when the particle interacts with the analyte. - View Dependent Claims (101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147)
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148. A sensor array for detecting an analyte in a fluid comprising:
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a supporting member;
wherein a first cavity and a second cavity are formed within the supporting member;
a first particle positioned within the first cavity;
a second particle positioned within the second cavity, wherein the second particle comprises a reagent, wherein a portion of the reagent is removable from the second particle when contacted with a decoupling solution, and wherein the reagent is configured to modify first particle, when the reagent is contacted with the first particle, such that the first particle will produce a signal when the first particle interacts with the analyte during use;
a first pump coupled to the supporting member, wherein the pump is configured to direct the fluid towards the first cavity;
a second pump coupled to the supporting member, wherein the second pump is configured to direct the decoupling solution towards the second cavity;
wherein a first channel is formed in the supporting member, the first channel coupling the first pump to the first cavity such that the fluid flows through the first channel to the first cavity during use, and wherein a second channel is formed in the supporting member, the second channel coupling the second cavity to the first cavity such that the decoupling solution flows from the second cavity through the second channel to the first cavity during use. - View Dependent Claims (149, 150, 151, 152)
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153. A sensor array for detecting an analyte in a fluid comprising:
at least one particle coupled to a supporting member, wherein the particle is configured to produce a signal when the particle interacts with the analyte. - View Dependent Claims (154, 155, 157, 158, 159, 160)
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161. A method for forming a sensor array configured to detect an analyte in a fluid, comprising:
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forming a cavity in a supporting member, wherein the supporting member comprises a silicon wafer;
placing a particle in the cavity, wherein the particle is configured to produce a signal when the particle interacts with the analyte; and
forming a cover upon a portion of the supporting member, wherein the cover is configured to inhibit dislodgement of the particle from the cavity. - View Dependent Claims (162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196)
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184. The method of claim further comprising forming a pump on the supporting member, the pump being configured to pump the fluid to the cavity.
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197. A method of sensing an analyte in a fluid comprising:
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passing a fluid over a sensor array, the sensor array comprising at least one particle positioned within a cavity of a supporting member;
monitoring a spectroscopic change of the particle as the fluid is passed over the sensor array, wherein the spectroscopic change is caused by the interaction of the analyte with the particle. - View Dependent Claims (198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252)
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253. A particle for detecting an analyte in a fluid comprising:
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a polymeric resin;
a biopolymer coupled to the polymeric resin; and
an indicator system coupled to the biopolymer, the indicator system producing a signal, and in the biopolymer undergoes a chemical reaction in the presence of the analyte such that the signal is altered. - View Dependent Claims (254, 255, 256, 257, 258, 259, 260, 261, 262, 263)
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264. A particle for detecting an analyte in a fluid comprising:
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a polymeric resin;
a receptor coupled to the polymeric resin; and
a probe molecule coupled to the biopolymer, the probe molecule configured to produce a signal when the receptor interacts with the analyte during use. - View Dependent Claims (265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277)
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278. A particle for detecting an analyte in a fluid comprising:
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a polymeric resin;
a receptor coupled to the polymeric resin by a first linker; and
an indicator coupled to the first linker, the indicator configured to produce a signal when the receptor interacts with the analyte during use. - View Dependent Claims (279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300)
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301. A particle for detecting an analyte in a fluid comprising:
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a polymeric resin;
a biopolymer coupled to the polymeric resin; and
an indicator system coupled to the biopolymer, the indicator system producing a signal during use, and wherein the biopolymer undergoes a chemical reaction in the presence of the analyte such that the signal is altered during use. - View Dependent Claims (302, 303, 304, 305, 308)
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306. The particle of claim 689, wherein the first indicator is a fluorescent dye and wherein the second indicator is a fluorescence quencher, and wherein the first indicator and the second indicator are positioned such that the fluorescence of the first indicator is at least partially quenched by the second indicator, and wherein the chemical reaction of the biopolymer in the presence of the analyte causes the first and second indicators to move such that the quenching of the fluorescence of the first indicator by the second indicator is altered.
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307. The particle of claim 689, wherein the first indicator is a fluorescent dye and wherein the second indicator is a different fluorescent dye, and wherein the first indicator and the second indicator produce a fluorescence resonance energy transfer signal, and wherein the chemical reaction of the biopolymer in the presence of the analyte causes the positions of the first and second indicators to change such that the fluorescence resonance energy transfer signal is altered.
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309. A method for collecting and transmitting chemical information comprising:
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detecting one or more analytes with an analyte detection device, wherein the analyte detection device includes communication hardware configured to transmit chemical information; and
transmitting the chemical information over a computer network to a client computer system coupled to the computer network, wherein the client computer system comprises is configured to receive the chemical information over the computer network. - View Dependent Claims (310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342)
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343. A system for collecting and transmitting chemical information, the system comprising:
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an analyte detection device, operable to detect one or more analytes and produce output signifying the detection of one or more analytes in the form of chemical information; and
a client computer system connected to the computer network, wherein the client computer system comprises a software program executable to receive the chemical information over a computer network, and wherein the analyte detection device comprises communication hardware and software executable to transmit the chemical information over a computer network to other computer systems. - View Dependent Claims (344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374)
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375. A system for detecting an analyte in a fluid comprising:
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a light source;
a sensor array, the sensor array comprising a supporting member comprising at least one cavity formed within the supporting member;
a particle, the particle positioned within the cavity, wherein the particle is configured to produce a signal when the particle interacts with the analyte during use;
a detector, the detector being configured to detect the signal produced by the interaction of the analyte with the particle during use; and
communication hardware and software executable to transmit chemical information to a computer system;
wherein the light source and detector are positioned such that light passes from the light source, to the particle, and onto the detector during use. - View Dependent Claims (376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395, 396)
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397. A method for using a testing device in a remote location, comprising the steps of:
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providing a sample to a replaceable sensor cartridge having multiple analyte sensors and being configured as part of the testing device, the sample being from a subject and provided to the replaceable sensor cartridge by an operator;
transmitting electronic data regarding the sample to a central data service;
executing at least one test on the electronic data using the central data service; and
transmitting an electronic message to a third party, the message having an initial result of the at least one test to a third party. - View Dependent Claims (398, 399)
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400. A method for diagnostic screening of a subject using a remote testing device, comprising the steps of:
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prescribing a treatment to a subject by a third party;
applying a screening quantity of the treatment to the subject;
after a predetermined period of time, providing a sample to a replaceable sensor package attached to the remote testing device;
transmitting electronic test data to a central data service, the electronic test data representing a change condition as part of a diagnostic test; and
interpreting the electronic test data at the central data service to provide test results related to the treatment to the subject. - View Dependent Claims (401, 402, 403, 404, 405, 406)
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407. A method of selectively scheduling an office visit using a remote testing device, comprising the steps of:
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sending electronic test data related to a test sample from a remote location to a central data service, the test sample being related to a subject being tested;
interpreting the electronic test data to provide test results at the central data service;
transmitting the test results to a third party via an electronic message from the central data service; and
remotely scheduling an office visit by the third party and for the subject being tested based on the transmitted test results. - View Dependent Claims (408, 409)
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410. A method of medical treatment using a remote testing device, comprising the steps of:
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gathering electronic test data on a sample related to a subject who is under the medical supervision of a third party;
sending the electronic test data to a central service for analysis;
transmitting test results to the third party, the test results being based upon the analysis by the central data service;
determining if the subject requires an office visit based upon the test results; and
determining if the subject should alter a prescribed treatment based on test data. - View Dependent Claims (411, 412, 413, 414)
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415. A method for using a testing device in a remote location, comprising the steps of:
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logging into the testing device with operator identification information;
identifying the subject to the testing device with subject identification information;
collecting a test sample from the subject using the testing device;
providing the test sample to at least one sensor array on the testing device;
electronically sensing a color change in the at least one sensor array;
processing electronic test data related to the sensed color change;
transmitting the processed electric test data and associated identification information to a central data service for remote analysis by the central data service, the type of analysis to be performed being indicated by the associated identification information; and
receiving test results from the remote analysis by the central data service, the test results being stored by the central data service and electronically transmitted to a third party.
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Specification