Anti-ADDL antibodies and uses thereof
First Claim
1. A composition comprising one or more antibodies that interacts preferentially with soluble, non-fibrillar oligomeric assemblies of amyloid β
- protein.
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Accused Products
Abstract
The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
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Citations
18 Claims
- 1. A composition comprising one or more antibodies that interacts preferentially with soluble, non-fibrillar oligomeric assemblies of amyloid β
- 4. A composition comprising one or more antibodies that bind preferentially to soluble, globular, non-fibrillar protein assemblies of amyloid β
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7. A composition comprising antibodies that bind preferentially to amyloid β
- -derived diffusible ligands (ADDLs).
- View Dependent Claims (8)
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9. A composition comprising one or more antibody binding sites that bind preferentially to ADDLs.
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10. A composition comprising one or more modified antibody binding sites that bind preferentially to ADDLs.
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11. A composition consisting of one or more binding sites that preferentially bind to ADDLs.
Specification