Vascular tissue engineering
First Claim
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1. A tubularized tissue made according to the steps of:
- seeding a cell on the exterior surface of scaffold so as to obtain a scaffold encircled by cells;
incubating said scaffold encircled by said cells so as to form a tubularized tissue;
thereby obtaining a tubularized tissue.
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Abstract
The invention relates to tubularized tissue, which in one embodiment is a vascular tissue made by seeding cells on the exterior surface of a scaffold and incubating of the cells so as to form a tubular tissue with the scaffold inside. In another embodiment the invention relates to a hybrid tissue. In another embodiment, the invention relates to methods of using the same for example, for enhancing blood vessel formation in a patient, for promoting angiogenesis and vasculogenesis, for replacing damaged blood vessel and for determining cellular or tissue function of an agent.
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Citations
124 Claims
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1. A tubularized tissue made according to the steps of:
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seeding a cell on the exterior surface of scaffold so as to obtain a scaffold encircled by cells;
incubating said scaffold encircled by said cells so as to form a tubularized tissue;
thereby obtaining a tubularized tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 83, 84, 85, 88, 89, 90, 91, 92, 93, 94, 95, 96)
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29. A method of maturing cells into a tubularized tissue comprising the following steps:
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seeding a cell on the exterior surface of scaffold so as to obtain a scaffold encircled by cells;
incubating said scaffold encircled by said cells so as to form a tubularized tissue;
thereby maturing cells into a tubularized tissue. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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56. A method of enhancing blood vessel formation in a patient in need thereof, comprising the following steps:
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selecting the patient in need thereof;
isolating a cell from the patient;
seeding a cell on the exterior surface of scaffold so as to obtain a scaffold encircled by cells;
incubating said scaffold encircled by said cells so as to form a tubularized tissue; and
readministering said tubularized tissue to the patient in need thereof, thereby enhancing blood vessel formation in a patient in need thereof. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82)
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- 86. A method of replacing a damaged blood vessel of a patient comprising the step of administering to the patient an effective amount of the tubularized tissue, thereby replacing damaged blood vessels.
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97. A hybrid tissue made according to the steps of:
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seeding a cell that will form a first tissue type on the exterior surface of a branched scaffold so as to obtain a scaffold encircled by cells with spaces in between;
adding into said spaces in between, a cell that will form a second tissue type; and
incubating so as to obtain a hybrid tissue. - View Dependent Claims (98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124)
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Specification