Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
First Claim
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1. A vaccine for treatment of candidiasis comprising a pharmaceutically effective amount of a peptide mimotope specific to the mannan portion of the phosphomannan complex of Candida which elicits an immune response.
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Abstract
A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
16 Citations
33 Claims
- 1. A vaccine for treatment of candidiasis comprising a pharmaceutically effective amount of a peptide mimotope specific to the mannan portion of the phosphomannan complex of Candida which elicits an immune response.
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11. A vaccine for treatment of disseminated candidiasis comprising a pharmaceutical effective amount of an epitope mimic of Candida albicans comprising a peptide mimotope specific for β
- 1,2-trimannose or acid stable epitopes thereof, that elicit an immune response.
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12. A therapeutic composition for treatment of disseminated candidiasis comprising a pharmaceutical effective amount of passive humoral antibodies to Candida albicans directed against a peptide mimotope specific for the β
- 1,2-trimannose or an epitope in the acid stable region of the mannan portion of the phospho-mannan complex of Candida albicans that elicits an immune response.
- 13. Isolated protective antibodies for passive protection against hematogenous disseminated candidiasis and mucocutaneous candidiasis.
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14. Monoclonal antibodies specific for a peptide mimotope of mannan epitopes in the acid stable portion of the mannan epitope and β
- -1,2-linked tri, tetra- and penta-mannosyl residues in the acid labile part of the mannan portion of the phosphomannoprotein complex.
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17. A monoclonal antibody specific for peptide mimotopes of C. albicans phosphomannoprotein.
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19. A method for immunization against candidiasis comprising generating Candida albicans peptides specific for phosphomannan complex neutralizing antibodies.
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22. A peptide specific to the mannan portion of the phosphomannan complex of Candida wherein said peptide has the amino acid sequence YRQFVTGFW;
- where;
Y, tyrosine;
R, arginine;
Q, glutamine;
F, phenylalanine;
V, valine;
T, threonine;
G, glycine;
W, tryptophan, or function equivalents of said peptide. - View Dependent Claims (23)
- where;
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32. A novel method for vaccination against non-protein epitopes of Candida, wherein said vaccine is comprised of polynucleotides encoding peptide mimotopes of the non-protein epitopes.
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33. A novel method with broad application for vaccination against non-protein epitopes (e.g., carbohydrate, lipid), wherein said vaccine is comprised of polynucleotides encoding peptide mimotopes of non-protein epitopes.
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