Enhanced pharmacokinetic profile of intradermally delivered substances
First Claim
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1. A method for directly delivering a substance into an intradermal space within a mammal, the method comprising administering said substance into the intradermal space, whereby the administered substance has improved pharmacokinetics relative to the same substance when administered subcutaneously to the same mammal.
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Abstract
A method for administration of a substance into the dermis of a mammal is disclosed. The method involves administration into the dermis by injection which results in improved systemic absorption relative to that obtained upon subcutaneous administration of the substance. The substance administered may be a growth hormone, a low molecular weight heparin or a dopamine receptor agonist.
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Citations
84 Claims
- 1. A method for directly delivering a substance into an intradermal space within a mammal, the method comprising administering said substance into the intradermal space, whereby the administered substance has improved pharmacokinetics relative to the same substance when administered subcutaneously to the same mammal.
- 23. A method of administering a pharmaceutical substance comprising injecting the substance intradermally through one or more microneedles having a length and outlet suitable for selectively delivering the substance into the dermis to obtain absorption of the substance in the dermis.
- 36. A microneedle for intradermal injection of a pharmaceutical substance, wherein the microneedle has a length and outlet selected for its suitability for specifically delivering the substance into the dermis.
- 44. A method for administering a macromolecular and/or hydrophobic pharmaceutical substance to a patient, the method comprising selectively delivering the substance intradermally to achieve a substantially higher Cmax and/or a substantially shorter Tmax and/or a substantially shorter time to reach a threshold blood serum concentration for pharmaceutical effect of the substance, by comparison with subcutaneous administration of the substance at an identical dose and rate of delivery.
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68. A method for delivering a bioactive substance to a subject comprising:
contacting the skin of the subject with a device having a dermal-access means for accurately targeting the dermal space of the subject with an efficacious amount of the bioactive substance. - View Dependent Claims (69, 70, 71, 72, 73, 74, 75, 76)
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77. A method for delivering a bioactive substance to a subject comprising:
contacting the skin of a subject with a device having a dermal-access means for accurately targeting the dermal space of the subject with an efficacious amount of the bioactive substance at a rate of 1 nL/min to 200 ml/min. - View Dependent Claims (78, 79, 80, 81, 82, 83, 84)
Specification