Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
First Claim
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1. An MMP regulator comprising a zinc chelator and a TIMP-derived peptide.
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Abstract
The present invention relates to MMP regulators that comprise new synthetic peptides, that comprise amino acid sequences structurally similar to those of MMP binding region of TIMPs, coupled to zinc chelators. The invention also relates to methods for making these MMP regulators and their use for the treatment of chronic and acute wounds and for the treatment of angiogenesis-associated diseases.
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23 Claims
- 1. An MMP regulator comprising a zinc chelator and a TIMP-derived peptide.
- 8. A method of treating chronic or acute wounds comprising administering an MMP regulator comprising a zinc chelator and a TIMP-derived peptide.
- 15. A composition comprising a pharmaceutically acceptable carrier and an MMP regulator, wherein the MMP regulator comprises a zinc chelator and a TIMP-derived peptide.
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