Method and apparatus for dispensing inhalator medicament

• US 20030075172A1
• Filed: 10/08/2002
• Published: 04/24/2003
• Est. Priority Date: 10/19/2001
• Status: Active Grant

• Current Assignee: Zhejiang Hisun Pharmaceutical Company Limited (Hisun Pharmaceutical (Hangzhou) Co., Ltd.)
• Original Assignee: Respirics, Inc.
• Inventors: Johnson, Keith A., Casper, Robert A., Gardner, David L.
• Granted Patent: US 7,931,022 B2
• Time in Patent Office: Days
• US Class Current: 128/200.24
• CPC Class Codes: A61J 1/035 Blister-type containers blisters in general B65D75/36
• CPC Class Codes: A61M 15/0003 with means for dispensing more than one drug
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0048 the dosages being arranged in a plane, e.g. on diskettes
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: B65D 81/3261 Flexible containers having several compartments

Abstract

An apparatus and method for delivering a plurality of medication includes providing first and second medicament on a medicament pack in separate containers for preventing either medicament from interfering with the stability of the other. In accordance with the method, the medicaments are preferably delivered in a single inhalation.

Claims

1. A dry powder medicament inhalator delivery system in which two or more different medicament formulations are delivered in a single inspired breath wherein the delivery system is comprised of:

a dry powder inhalator for providing control of medicament introduction into a patient'"'"'s inspired air stream; and

a medicament packaging system comprising at least one dose each of two or more different medicament formulations.

2. A dry powder medicament inhalator system of claim 1, wherein the medicament package consists of a single dose each of two or more different medicament formulations on a single blister card.

3. A dry powder medicament inhalator system of claim 1, wherein the medicament package consists of two or more medicaments, at least one of the medicaments being disposed in blisters disposed in a circular pattern.

4. A dry powder medicament inhalator system of claim 3, wherein the medicament comprises two medicaments, each being disposed in blisters arranged in a circular pattern.

5. A dry powder medicament inhalator of claim 4, wherein the blisters are arranged in concentric circles.

6. A dry powder inhalator of claim 1 in which the individual blisters of different medications comprising a dosing position are exposed for inhalation by piercing each of the individual blisters.

7. A blister pack for delivering medicament for inhalation, the blister pack comprising at least two blisters containing different medicaments.

8. The blister pack for delivering medicament of claim 7, wherein the blister pack comprises a plurality of blisters disposed in a circular pattern.

9. The blister pack for delivering medicament of claim 8, wherein the blister pack comprises a first circular pattern of blisters having a first medicament and a second circular pattern of blisters having a second medicament.

10. The blister pack for delivering medicament of claim 9, wherein the first circular pattern and the second circular pattern overlap.

11. The blister pack for delivering medicament of claim 9, wherein the circular patterns are concentric.

12. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for treating respiratory diseases.

13. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for oncology diseases.

14. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for treating infectious diseases.

15. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for treating bone degenerative diseases.

16. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for treating neurological degenerative diseases.

17. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for pain management.

18. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for treating cardiovascular disease.

19. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for treating arthritis.

20. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for treating hypertension.

21. The blister pack for delivering medicament of claim 7, wherein at least one of the medicaments comprises a medicament for treating neurological disorders.

22. A method for delivering medication, the method comprising:

selecting a medicament pack having at least a first medicament and a second medicament isolated from one another; and

opening the delivery pack so as to enable inhalation of the first medicament and the second medicament in a single inhalation.

23. The method according to claim 22, wherein the method comprises disposing the medicament pack in an inhalator.

24. The method according to claim 23, wherein the method comprises inhaling the first medication and the second medication simultaneously.

25. The method according to claim 23, wherein the method comprises inhaling most of the first medication prior to inhalation of the second medication.

26. The method according to claim 22, wherein the first medicament is selected for treating oncology diseases.

27. The method according to claim 22, wherein the first medicament is selected for treating infectious diseases.

28. The method according to claim 22, wherein the first medicament is selected for treating bone degenerative diseases.

29. The method according to claim 22, wherein the first medicament is selected for treating neurological degenerative diseases.

30. The method according to claim 22, wherein the first medicament is selected for pain management.

31. The method according to claim 22, wherein the first medicament is selected for treating cardiovascular disease.

32. The method according to claim 22, wherein the first medicament is selected for treating arthritis.

33. The method according to claim 22, wherein the first medicament is selected for treating hypertension.

34. The method according to claim 22, wherein the first medicament is selected for treating respiratory diseases.

35. The method according to claim 22, wherein the first medicament is selected for treating neurological disorders.

36. The method according to claim 22, wherein the first medicament is selected for diagnosing respiratory diseases.

37. An inhaler for delivery medicament, the inhaler comprising:

a first inflow channel disposable in communication with a first medicament;

a second inflow channel disposable in communication with a second medicament; and

an inhalation channel in communication with the first inflow channel and the second inflow channel for inhaling a first medicament and a second medicament.

38. The inhaler of claim 37, further comprising a flap for selectively limiting airflow between the inhalation channel and at least one of the first inflow channel and the second inflow channel.

39. An inhaler for delivering medicament, the inhaler comprising:

at least one airflow channel through which medicament is inhaled;

a first medicament; and

a second medicament, packaged separately from the first medicament.

40. A blister pack for delivering medicament for inhalation, the blister pack comprising at least a first medicament selected from the group consisting of powders, microcapsules and microspheres, and at least a second medicament selected from the group consisting of powers, microcapsules and microspheres, the first medicament and the second medicament being disposed in separate blisters.