Use of high-purity phenylsilsesquioxane liquids for the preparation of cosmetic and pharmaceutical compositions

• US 20030077240A1
• Filed: 10/24/2001
• Published: 04/24/2003
• Est. Priority Date: 10/24/2001
• Status: Abandoned Application

• Current Assignee: Clariant International Ltd (Clariant AG)
• Original Assignee: Clariant International Ltd (Clariant AG)
• Inventors: Terry, W. Leonard Jr., Figueroa, Ray, LeGrow, Gary E.
• Application Number:
  US10/002,709
• Publication Number:
  US 20030077240A1
• Time in Patent Office: Days
• US Class Current: 424/70.121
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/585 Organosilicon compounds
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 5/06 Preparations for styling the hair, e.g. by temporary shaping or colouring
• CPC Class Codes: A61Q 5/12 Preparations containing hair conditioners

Abstract

The invention relates to the use of phenylsilsesquioxane liquids of the general composition

Me₃SiO—[Si(OSiMe₃)(Ph)O]_x—SiMe₃

wherein Me is methyl, Ph is phenyl and x is an integer between 1 and 8, and wherein the phenylsilsesquioxanes are substantially free from alkoxysilanes, chlorosilanes, silanols, hexamethyldisiloxanes, organic compounds and inorganic compounds, for the preparation of cosmetic and pharmaceutical compositions.

Claims

1. The use of phenylsilsesquioxane liquids of the general composition

Me₃SiO—

[Si(OSiMe₃)(Ph)O]_x—

SiMe₃

wherein Me is methyl, Ph is phenyl and x is an integer between 1 and 8, and wherein the phenylsilsesquioxanes are substantially free from alkoxysilanes, chlorosilanes, silanols, hexamethyidisiloxanes, organic compounds and inorganic compounds, for the preparation of cosmetic and pharmaceutical compositions.

2. The use as claimed in claim 1, wherein the phenylsilsesquioxane liquids have a purity equal to or greater than 99.5% by weight, preferably equal to or greater than 99.9% by weight.

3. The use as claimed in claim 1, wherein x in the general composition has values from 1 to 3, preferably the value 1.

4. The use as claimed in claim 1, wherein the phenylsilsesquioxane liquids have viscosities of from 5 cs to 2000 cs, preferably 10 to 1000 cs, particularly preferably 25 cs to 500 cs, at a temperature of 25°

C.

5. The use as claimed in claim 1, wherein the cosmetic and pharmaceutical compositions are rinse-off or leave-on products.

7. The use as claimed in claim 1, wherein

the phenylsilsesquioxane liquids are prepared by

a) i) hydrolyzing a mixture of pure trimethylchlorosilane and pure phenyltrichlorosilane with distilled water, the amount of water being chosen such that it is sufficient to form an aqueous layer which comprises less than 25% by weight of hydrochloric acid, and where the temperature of the hydrolysis reaction is maintained below 90° C. in order to form a silicone intermediate;

then

ii) removing the residual acid from the silicone intermediate;

then

iii) azeotropically removing the water from the washed silicone intermediate, and converting the latter into a dried silicone intermediate; and

subsequently

b) trimethylsilylating the silanol groups in the dried silanol intermediate with at least a stoichiometric amount of hexamethyldisiloxane in the presence of an acidic catalyst.

6. The use of phenylsilsesquioxane liquids of the general composition

Me₃SiO—

[Si(OSiMe₃)(Ph)O]_x—

SiMe₃

wherein Me is methyl, Ph is phenyl and x is an integer between 1 and 8, and wherein the phenylsilsesquioxanes are substantially free from alkoxysilanes, chlorosilanes, silanols, hexamethyldisiloxanes, organic compounds and inorganic compounds, as spreading agent, dispersant, bodying agent, carrier, glidant, conditioner, repellent and luster agent in cosmetic and pharmaceutical compositions.