Contact lens treating method and composition

• US 20030078171A1
• Filed: 02/07/2001
• Published: 04/24/2003
• Est. Priority Date: 02/16/2000
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Tsao, Fu-Pao
• Granted Patent: US 6,569,824 B2
• Time in Patent Office: Days
• US Class Current: 510/112
• CPC Class Codes: A61L 12/124 Hydrogen peroxide; Peroxy compounds
• CPC Class Codes: C11D 17/0073 Tablets
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/3945 Organic per-compounds C11D3/3902 takes precedence
• CPC Class Codes: C11D 3/3947 Liquid compositions

Abstract

A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.

Claims

1. A method of disinfecting a contact lens, comprising:

treating said lens with an aqueous solution containing an effective amount of a monoperphthalic acid compound in a concentration of less than 0.5% by weight of said solution.

2. The method of claim 1 wherein the treating step comprises soaking the contact lens in the aqueous solution.

3. The method of claim 1 in which prior to the treating step the following steps occur:

(a) providing a dry component having said monoperphthalic acid compound;

(b) providing a wet component; and

(c) combining the dry component and the wet component to form an aqueous solution for treating said lens.

4. The method of claim 3 in which the wet component is saline.

5. The method of claim 3 in which the wet component is deionized water.

6. The method of claim 1 wherein the monoperphthalic acid compound is a monoperphthalic acid salt.

7. The method of claim 1 wherein the monoperphthalic acid compound is selected from the group of compounds consisting of:

magnesium monoperphthalate hexahydrate, magnesium monoperoxyphthalate hydrates, calcium monoperphthalate, sodium monoperphthalates, sodium monoperoxyphthalates, potassium monoperphthalates, potassium monoperoxyphthalates, magnesium perphthalates, calcium perphthalates, potassium perphthalates, sodium perphthalates, sodium potassium perphthalates, potassium hydrogen perphthalates, sodium hydrogen perphthalate, potassium acid perphthalates, perphthalic acid, monoperphthalic acid, magnesium perphthalate hexahydrates, perphthalate hydrates, 1,2 benzenedicarboperoxoic acid alkali metal salts, 1,2 benzenedicarboperoxoic acid dialkali metal salts, 2-carboxy benzenecarboperoxoic acid salts, 2-carboxy benzenemonocarboperoxoic acid alkaline earth metal salts, 2-carboxy benzenemonocarboperoxoic acid alkali metal salts, 2-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 2-carboxy benzenemonocarboperoxoic acid alkaline earth metal hydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkali metal salts, 3-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkaline metal hexahydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 4-carboxy benzenemonocarboperoxoic acid alkali metal hexahydrate salts, 4-carboxy benzenemonocarboperoxoic acid alkali metal salts, 4-carboxy benzenemonocarboperoxoic acid alkaline metal hydrate salts, 4-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 5-carboxy benzenemonocarboperoxoic acid alkali metal salts, 5-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 5-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 5-carboxy benzenemonocarboperoxoic acid alkaline metal hydrate salts, 1,2-benzene dicarboperoxoic acid alkaline earth metal salts, 1,2-benzene dicarboperoxoic acid alkaline earth metal hydrate salts, 1,2-benzene dicarboperoxoic acid monoalkali metal salts, 1,2-benzene dicarboperoxoic acid dialkali metal salts, 1,2-benzene dicarboperoxoic acid, 1,3-benzene dicarboperoxoic acid alkaline earth metal salts, 1,3 benzene dicarboperoxoic acid, 1,3-benzene dicarboperoxoic acid monoalkali metal salts, 1,3-benzene dicarboperoxoic acid dialkali metal salts, 1,4-benzene dicarboperoxoic acid, 1,4-benzene dicarboperoxoic acid monoalkali metal salts, 1,4-benzene dicarboperoxoic acid dialkali metal salts, 1,4-benzene dicarboperoxoic acid alkeline earth metal salts, 1,5-benzene dicarboperoxoic acid, 1,5-benzene dicarboperoxoic acid monoaliali metal salts, 1,5-benzene dicarboperoxoic acid dialkali metal salts, and 1,5-benzene dicarboperoxoic acid alkaline earth metal salts.

8. A method of treating a contact lens, comprising:

(a) providing a dry component having a monoperphthalic acid compound;

(b) providing a wet component;

(c) combining the dry component and wet component to form an aqueous lens treating solution having less than 0.5% by weight monoperphthalic acid compound; and

(d) treating the lens with the aqueous lens treating solution.

9. The method of treating a contact lens as in claim 8 wherein the monoperphthalic acid compound is provided in a concentration of about 0.25% by weight of said solution.

10. The method of treating a contact lens as in claim 8 wherein the monoperphthalic acid compound is provided in a concentration of about 0.125% by weight of said solution.

11. The method of treating a contact lens as in claim 8 wherein the monoperphthalic acid compound is provided in a concentration of about 0.06% by weight of said solution.

12. The method of claim 8 in which the dry component comprises a granular compound.

13. The method of claim 8 in which the dry component comprises a tablet that is capable of dissolving in the wet component.

14. The method of claim 8 in which the dry component is a tablet and the wet component is saline.

15. The method of claim 8 in which the dry component is a tablet and the wet component is deionized water.

16. A method of treating a contact lens, comprising:

(a) providing a first compound selected from the group of compounds consisting of;

magnesium monoperphthalate hexahydrate, magnesium monoperoxyphthalate hydrates, calcium monoperphthalate, sodium monoperphthalates, sodium monoperoxyphthalates, potassium monoperphthalates, potassium monoperoxyphthalates, magnesium perphthalates, calcium perphthalates, potassium perphthalates, sodium perphthalates, sodium potassium perphthalates, potassium hydrogen perphthalates, sodium hydrogen perphthalate, potassium acid perphthalates, perphthalic acid, monoperphthalic acid, magnesium perphthalate hexahydrates, perphthalate hydrates, 1,2 benzenedicarboperoxoic acid alkali metal salts, 1,2 benzenedicarboperoxoic acid dialkali metal salts, 2-carboxy benzenecarboperoxoic acid salts, 2-carboxy benzenemonocarboperoxoic acid alkaline earth metal salts, 2-carboxy benzenemonocarboperoxoic acid alkali metal salts, 2-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 2-carboxy benzenemonocarboperoxoic acid alkaline earth metal hydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkali metal salts, 3-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkaline metal hexahydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 4-carboxy benzenemonocarboperoxoic acid alkali metal hexahydrate salts, 4-carboxy benzenemonocarboperoxoic acid alkali metal salts, 4-carboxy benzenemonocarboperoxoic acid alkaline metal hydrate salts, 4-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 5-carboxy benzenemonocarboperoxoic acid alkali metal salts, 5-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 5-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 5-carboxy benzenemonocarboperoxoic acid alkaline metal hydrate salts, 1,2-benzene dicarboperoxoic acid alkaline earth metal salts,1,2-benzene dicarboperoxoic acid alkaline earth metal hydrate salts, 1,2-benzene dicarboperoxoic acid monoalkali metal salts, 1,2-benzene dicarboperoxoic acid dialkali metal salts, 1,2-benzene dicarboperoxoic acid, 1,3-benzene dicarboperoxoic acid alkaline earth metal salts, 1,3 benzene dicarboperoxoic acid, 1,3-benzene dicarboperoxoic acid monoalkali metal salts, 1,3-benzene dicarboperoxoic acid dialkali metal salts, 1,4-benzene dicarboperoxoic acid, 1,4-benzene dicarboperoxoic acid monoalkali metal salts, 1,4-benzene dicarboperoxoic acid dialkali metal salts, 1,4-benzene dicarboperoxoic acid alkeline earth metal salts, 1,5-benzene dicarboperoxoic acid, 1,5-benzene dicarboperoxoic acid monoaliali metal salts, 1,5-benzene dicarboperoxoic acid dialkali metal salts, and 1,5-benzene dicarboperoxoic acid alkaline earth metal salts;

(b) providing a wet component;

(c) combining the first compound and the wet component to form an aqueous lens treating solution, wherein said solution comprises less than about 0.5% by weight of said first compound; and

(d) treating said contact lens with the aqueous lens treating solution.

17. The method of claim 16 in which the wet component additionally comprises a chloride-containing compound.

18. The method of claim 16 wherein the first compound is provided in a concentration of about 0.25% by weight of said solution.

19. The method of treating a contact lens as in claim 16 wherein the first compound is provided in a concentration of about 0.125% by weight of said solution.

20. The method of treating a contact lens as in claim 16 wherein the monoperphthalic acid compound is provided in a concentration of about 0.06% by weight of said solution.

21. The method of claim 16 in which the dry component comprises a granular compound.

22. The method of claim 16 in which the dry component comprises a tablet that is capable of dissolving in the wet component.

23. The method of claim 16 in which the dry component is a tablet and the wet component is saline.

24. The method of claim 16 in which the dry component is a tablet and the wet component is deionized water.

25. A low toxicity compound for treating contact lenses in aqueous solution, comprising a compound that is effective at an aqueous concentration of no more than about 0.5% by weight of said solution, said compound being selected from the group of compounds consisting of:

magnesium monoperphthalate hexahydrate, magnesium monoperoxyphthalate hydrates, calcium monoperphthalate, sodium monoperphthalates, sodium monoperoxyphthalates, potassium monoperphthalates, potassium monoperoxyphthalates, magnesium perphthalates, calcium perphthalates, potassium perphthalates, sodium perphthalates, sodium potassium perphthalates, potassium hydrogen perphthalates, sodium hydrogen perphthalate, potassium acid perphthalates, perphthalic acid, monoperphthalic acid, magnesium perphthalate hexahydrates, perphthalate hydrates, 1,2 benzenedicarboperoxoic acid alkali metal salts, 1,2 benzenedicarboperoxoic acid dialkali metal salts, 2-carboxy benzenecarboperoxoic acid salts, 2-carboxy benzenemonocarboperoxoic acid alkaline earth metal salts, 2-carboxy benzenemonocarboperoxoic acid alkali metal salts, 2-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 2-carboxy benzenemonocarboperoxoic acid alkaline earth metal hydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkali metal salts, 3-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkaline metal hexahydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 4-carboxy benzenemonocarboperoxoic acid alkali metal hexahydrate salts, 4-carboxy benzenemonocarboperoxoic acid alkali metal salts, 4-carboxy benzenemonocarboperoxoic acid alkaline metal hydrate salts, 4-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 5-carboxy benzenemonocarboperoxoic acid alkali metal salts, 5-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 5-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 5-carboxy benzenemonocarboperoxoic acid alkaline metal hydrate salts, 1,2-benzene dicarboperoxoic acid alkaline earth metal salts, 1,2-benzene dicarboperoxoic acid alkaline earth metal hydrate salts, 1,2-benzene dicarboperoxoic acid monoalkali metal salts, 1,2-benzene dicarboperoxoic acid dialkali metal salts, 1,2-benzene dicarboperoxoic acid, 1,3-benzene dicarboperoxoic acid alkaline earth metal salts, 1,3 benzene dicarboperoxoic acid, 1,3-benzene dicarboperoxoic acid monoalkali metal salts, 1,3-benzene dicarboperoxoic acid dialkali metal salts, 1,4-benzene dicarboperoxoic acid, 1,4-benzene dicarboperoxoic acid monoalkali metal salts, 1,4-benzene dicarboperoxoic acid dialkali metal salts, 1,4-benzene dicarboperoxoic acid alkeline earth metal salts, 1,5-benzene dicarboperoxoic acid, 1,5-benzene dicarboperoxoic acid monoaliali metal salts, 1,5-benzene dicarboperoxoic acid dialkali metal salts, and 1,5-benzene dicarboperoxoic acid alkaline earth metal salts.

26. An aqueous contact lens treating composition comprising:

less than about 0.5% by weight of a monoperphthalate compound having the general structure;

27. The composition of claim 26 further comprising a chloride-containing compound.

28. The composition of claim 26 wherein the composition is buffered such that during treating of the contact lens the composition has a pH of from about 6 to about 7.

29. A composition as in claim 26 in which the monoperphthalate compound is magnesium monoperphthalate.

30. The composition of claim 26 in which the composition comprises about 0.25% by weight of the monoperphthalate compound.

31. The composition of claim 26 in which the M⁺ⁿ cation is selected from the group consisting of:

sodium, magnesium, and potassium.

32. A tablet for treating a contact lens, comprising:

a first compound having relatively low biological toxicity in aqueous solution, wherein the first compound is effective at an aqueous concentration of no more than about 0.5% by weight of said compound in aqueous solution, said first compound being selected from the group consisting of;

magnesium monoperphthalate hexahydrate, magnesium monoperoxyphthalate hydrates, calcium monoperphthalate, sodium monoperphthalates, sodium monoperoxyphthalates, potassium monoperphthalates, potassium monoperoxyphthalates, magnesium perphthalates, calcium perphthalates, potassium perphthalates, sodium perphthalates, sodium potassium perphthalates, potassium hydrogen perphthalates, sodium hydrogen perphthalate, potassium acid perphthalates, perphthalic acid, monoperphthalic acid, magnesium perphthalate hexahydrates, perphthalate hydrates, 1,2 benzenedicarboperoxoic acid alkali metal salts, 1,2 benzenedicarboperoxoic acid dialkali metal salts, 2-carboxy benzenecarboperoxoic acid salts, 2-carboxy benzenemonocarboperoxoic acid alkaline earth metal salts, 2-carboxy benzenemonocarboperoxoic acid alkali metal salts, 2-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 2-carboxy benzenemonocarboperoxoic acid alkaline earth metal hydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkali metal salts, 3-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkaline metal hexahydrate salts, 3-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 4-carboxy benzenemonocarboperoxoic acid alkali metal hexahydrate salts, 4-carboxy benzenemonocarboperoxoic acid alkali metal salts, 4-carboxy benzenemonocarboperoxoic acid alkaline metal hydrate salts, 4-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 5-carboxy benzenemonocarboperoxoic acid alkali metal salts, 5-carboxy benzenemonocarboperoxoic acid alkali metal hydrate salts, 5-carboxy benzenemonocarboperoxoic acid alkaline metal salts, 5-carboxy benzenemonocarboperoxoic acid alkaline metal hydrate salts, 1,2-benzene dicarboperoxoic acid alkaline earth metal salts, 1,2-benzene dicarboperoxoic acid alkaline earth metal hydrate salts, 1,2-benzene dicarboperoxoic acid monoalkali metal salts, 1,2-benzene dicarboperoxoic acid dialkali metal salts, 1,2-benzene dicarboperoxoic acid, 1,3-benzene dicarboperoxoic acid alkaline earth metal salts, 1,3 benzene dicarboperoxoic acid, 1,3-benzene dicarboperoxoic acid monoalkali metal salts, 1,3-benzene dicarboperoxoic acid dialkali metal salts, 1,4-benzene dicarboperoxoic acid, 1,4-benzene dicarboperoxoic acid monoalkali metal salts, 1,4-benzene dicarboperoxoic acid dialkali metal salts, 1,4-benzene dicarboperoxoic acid alkeline earth metal salts, 1,5-benzene dicarboperoxoic acid, 1,5-benzene dicarboperoxoic acid monoaliali metal salts, 1,5-benzene dicarboperoxoic acid dialkali metal salts, and 1,5-benzene dicarboperoxoic acid alkaline earth metal salts.

33. A tablet for treating a contact lens, the tablet adapted for dissolving in aqueous solution to provide a substantially nontoxic lens disinfecting solution, the tablet comprising:

a monoperphthalate compound having the general structure;

or its pharmaceutically acceptable salts or esters, wherein M⁺ⁿ is a cation selected from the group consisting of an alkali metal, an alkaline earth metal, a nontoxic heavy metal, trimethyl ammonium and triethylammonium, and R is 1 or more substituents compatible with the peroxy acid functionality of the aromatic ring.