Degradable cross-linking agents and cross-linked network polymers formed therewith
First Claim
1. A monomeric or oligomeric cross-linker comprising a polyacid core with at least two acidic groups being connected to reactive groups usable to cross-link polymer filaments wherein between at least one reactive group and the polyacid core is a region degradable under aqueous conditions;
- the cross-linker being usable to form cross-linked polymer filaments.
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Accused Products
Abstract
Degradable cross-linkers which are used to form polymer networks which degrade under aqueous conditions are described. These cross-linkers comprise a central polyacid, monomeric or oligomeric degradable regions and an optional water soluble regions. These monomers are preferably polymerized using free radical or condensation polymerization. Degradation occurs at the ester linkages after cross-linking polymer filaments, and results in soluble polymer filaments which may be cleared from the body. Preferred applications of these materials include, for example, controlled release of drugs and cosmetics, tissue engineering, wound healing, hazardous waste remediation, metal chelation, swellable devices for absorbing liquids and the prevention of surgical adhesions.
163 Citations
35 Claims
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1. A monomeric or oligomeric cross-linker comprising a polyacid core with at least two acidic groups being connected to reactive groups usable to cross-link polymer filaments wherein between at least one reactive group and the polyacid core is a region degradable under aqueous conditions;
- the cross-linker being usable to form cross-linked polymer filaments.
- View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 34)
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2. A monomeric or oligomeric cross-linker comprising a polyacid core with at least two acidic groups connected to a region degradable under aqueous conditions and having a covalently attached reactive group usable to form cross-linked polymer filaments.
- 29. A network of polymer filaments formed by precipitation, dispersion or emulsion polymerization and cross-linked by a monomeric or oligomeric cross-linker having a polyacid core with at least two acidic groups connected to a covalently attached reactive group used to cross-link polymer filaments and at least one acidic group having a region degradable under aqueous conditions between the acidic group and the reactive group.
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30. A network of polymer filaments formed via condensation reaction of preformed polymer filaments of polynucleic acids, polypeptides, proteins or carbohydrates and cross-linked by a monomeric or oligomeric cross-linker comprising a polyacid core with at least two acidic groups connected to at least one region degradable under in vivo conditions, and having a covalently attached reactive group cross-linking the polymer filaments.
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32. A network of polymer filaments cross-linked by a monomeric or oligomeric cross-linker comprising a polyacid core with at least two acidic groups connected to at least one region degradable under in vivo conditions, and both acidic groups connected to a covalently attached reactive group and defined further as comprising an organic molecule, inorganic molecule, protein, carbohydrate, poly(nucleic acid), cell, tissue or tissue aggregate.
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33. A network of polymer filaments cross-linked by monomeric or oligomeric cross-linker comprising a central polyacid core with at least two acidic groups connected to at least one region degradable under in vivo conditions, and terminated by a covalently attached reactive end group usable to cross-link polymer filaments, the network comprising an organic radioisotope, inorganic radioisotope or nuclear magnetic resonance relaxation reagent.
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35. A microparticle or nanoparticle polymer composition containing a monomeric or oligomeric cross-linker comprising a polyacid core with at least two acidic groups connected to at least one region degradable under in vivo conditions, and having a covalently attached reactive group usable to cross-link polymer filaments.
Specification