Transthoracic drug delivery device
First Claim
1. A transthoracic drug delivery device comprising:
- a pressure sensing tube and a drug delivery tube joined to the pressure sensing tube in a parallel relationship, but staggered so that one tube extends beyond the other by a known distance.
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Accused Products
Abstract
The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressure sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, but its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug. In another embodiment, a steerable syringe is provided so that multiple sites in the myocardium can be treated with a therapeutic substance with only one penetration into the heart. Once the delivery tube of the syringe penetrates the left ventricle, its distal tip can be deflected back toward the endocardial surface and the tube withdrawn proximally to cause penetration of the tip into the myocardium. A pressure sensor mounted to the tube indicates, by a measured drop in pressure that the myocardium has been penetrated. The therapeutic substance is ejected into the myocardium and the device is then backed out of the tissue by advancing the syringe in a distal direction. The deflectable tip can be adjusted to a different deflection angle and the delivery tube rotated to make available a circular array of points that may be accessed by the syringe.
51 Citations
11 Claims
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1. A transthoracic drug delivery device comprising:
a pressure sensing tube and a drug delivery tube joined to the pressure sensing tube in a parallel relationship, but staggered so that one tube extends beyond the other by a known distance. - View Dependent Claims (2, 3, 4, 5)
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6. A method of delivering a therapeutic substance to the myocardium comprising:
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providing a delivery device comprised of a pressure sensing tube joined to at least one drug delivery tube maintained in parallel but staggered so that one extends beyond the other by a known distance that is less than the thickness of the myocardium;
Transthoracically accessing the heart;
inserting the tubes into the heart;
monitoring the pressure sensed by the tube while moving the device further into the heart;
stopping advancement of the device into the heart when a dramatic pressure increase is noted indicating pressure sensing tube has entered the ventricle and the delivery tube id within the myocardium;
ejecting a quantity of a therapeutic substance from the delivery tube into the myocardium.
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7. A steerable syringe comprising:
a delivery tube having a sharpened distal tip, a flexible distal portion, a distal tip, a port and a pull wire for deflecting the distal tip. - View Dependent Claims (8)
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9. A method of delivering a therapeutic substance to a plurality of sites in the myocardium with a single penetration into the heart comprising:
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introducing a tube having a deflectable distal portion and distal tip into the left ventricle of the heart;
deflecting the distal tip of the tube so that the tip faces the endocardium;
moving the tube in a proximal direction so that the distal tip penetrates the endocardium;
ejecting a therapeutic substance through the tube into the myocardium;
moving the distal tip from the myocardium by advancing the tube distally;
adjusting the position of the tip by changing the deflection angle of the tip or by rotating the tube to a new myocardial location;
moving the tube in a proximal direction to insert the distal tip into the myocardium at the new location;
ejecting a therapeutic substance from the tube into the myocardium. - View Dependent Claims (10)
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11. A transthoracic drug delivery device comprising:
a pressure sensing tube and a drug delivery tube joined to the pressure sensing tube.
Specification