Neuronal uses of BMP-11

• US 20030083252A1
• Filed: 12/20/2001
• Published: 05/01/2003
• Est. Priority Date: 05/12/1993
• Status: Abandoned Application

• Current Assignee: Genetics Institute LLC (Pfizer Inc.)
• Original Assignee: Genetics Institute LLC (Pfizer Inc.)
• Inventors: Thies, R. Scott, Wozney, John M., Celeste, Anthony J.
• Application Number:
  US10/029,016
• Publication Number:
  US 20030083252A1
• Time in Patent Office: Days
• US Class Current: 514/12
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/18 Feminine contraceptives
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: C07K 14/575 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin C07K14/665, e.g. corticotropin C07K14/695
• CPC Class Codes: C07K 2319/00 Fusion polypeptide
• CPC Class Codes: C12N 2501/155 Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
• CPC Class Codes: C12N 5/0619 Neurons
• CPC Class Codes: Y10S 930/12 Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Abstract

Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.

Claims

1. A method for modulating neuronal cell development in a mammal comprising the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:

2 and SEQ ID NO;

11; and

(b) administering said composition to said mammal.

2. A method for inducing neuronal cell formation, growth differentiation, proliferation, and maintenance in a mammal comprising the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:

2 and SEQ ID NO;

11; and

(b) administering said composition to said mammal.

3. A method of inducing formation of neuronal tissue in a mammal comprising the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:

2 and SEQ ID NO;

11; and

(b) administering said composition to said mammal.

4. A method of inducing formation of neuronal tissue, wherein said method comprises the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:

2 and SEQ ID NO;

11; and

(b) administering the composition to neuronal cells in vitro and recovering said tissue.

5. A method for maintaining neuronal tissue comprising the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:

2 and SEQ ID NO;

11; and

(b) administering said composition to said tissue.

6. A method for maintaining neuronal tissue comprising the step of administering a composition comprising BMP-11.