Use of benzenesulfonyl (thioureas or ure as) for treating of septic shock or gene ralized inflammatory syndrome
First Claim
1. A method of treating a patient suffering from septic shock or generalized inflammatory syndrome, comprising administering to the patient a pharmaceutically acceptable amount of a benzenesulfonyl(thiourea or urea) of formula I,
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Abstract
The present invention is directed to the use of a benzenesulfonyl(thiourea or urea) of formula I
wherein
R1 is hydrogen, (C1-C8)-alkyl-, (C3-C8)-cycloalkyl-, (C3-C8)-cycloalkyl-(C1-C4)-alkyl- or fluoro-(C1-C8)-alkyl-;
R2 is (C1-C6)-alkoxy-, (C3-C8)-cycloalkyloxy-, (C3-C8)-cycloalkyl-(C1-C4)-alkoxy-, (C1-C6)-alkoxy-(C1-C4)-alkoxy- or (C1-C6)-alkoxy-(C1-C4)-alkoxy-(C1-C4)-alkoxy-;
E is oxygen or sulfur;
Y is a hydrocarbon residue of formula —(CR32)n—, wherein the residues R3, all independently of each other, are hydrogen or (C1-C2)-alkyl, and n is 1, 2, 3 or 4;
X is hydrogen, halogen or (C1-C6)-alkyl; and
Z is halogen, (C1-C4)-alkyl-, fluoro-(C1-C4)-alkyl-, (C1-C4)-alkoxy- or fluoro-(C1-C4)-alkoxy-, or
a physiologically tolerable salt thereof or solvate thereof, for treating a patient suffering from septic shock or the generalized inflammatory syndrome (SIRS) comprising administering to the patient a pharmaceutically effective amount of the compound of formula I, or a physiologically tolerable salt thereof or solvate thereof.
The invention is also directed to the use of benzenesulfonyl(thioureas or ureas) of formula I, or a physiologically tolerable salt thereof or solvate thereof, for treating a patient suffering from pathological changes in blood pressure due to a septic shock or generalized inflammatory syndrome (SIRS) state, comprising administering to the patient a pharmaceutically effective amount of the compounds of formula I, or a physiologically tolerable salt thereof or solvate thereof.
14 Citations
21 Claims
- 1. A method of treating a patient suffering from septic shock or generalized inflammatory syndrome, comprising administering to the patient a pharmaceutically acceptable amount of a benzenesulfonyl(thiourea or urea) of formula I,
- 8. A method of treating a patient suffering from pathological changes in blood pressure arising from septic shock or generalized inflammatory syndrome, comprising administering to the patient a pharmaceutically acceptable amount of a benzenesulfonyl(thiourea or urea) of formula I,
- 15. A method of treating a patient suffering from a decrease in peripheral (systemic) blood pressure and, at the same time, an increase in pulmonary arterial pressure, comprising administering to the patient a pharmaceutically acceptable amount of a benzenesulfonyl(thiourea or urea) of formula I,
Specification
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Current AssigneeHeinrich Christian Englert, Heinz Gogelein, Klaus Wirth, Uwe Gerlach
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Original AssigneeHeinrich Christian Englert, Heinz Gogelein, Klaus Wirth, Uwe Gerlach
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InventorsWirth, Klaus, Englert, Heinrich Christian, Gogelein, Heinz, Gerlach, Uwe
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Application NumberUS10/178,648Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current514/584CPC Class CodesA61K 31/17 having the group >N—C(O)—N<...A61K 31/64 Sulfonylureas, e.g. glibenc...A61P 29/00 Non-central analgesic, anti...A61P 31/00 Antiinfectives, i.e. antibi...A61P 31/04 Antibacterial agentsA61P 43/00 Drugs for specific purposes...
