Small molecules used to increase cell death

• US 20030083386A1
• Filed: 07/16/2002
• Published: 05/01/2003
• Est. Priority Date: 12/13/1999
• Status: Active Grant

• Current Assignee: Alexei Degterev, Junying Yuan, Timothy J. Mitchison
• Original Assignee: Alexei Degterev, Junying Yuan, Timothy J. Mitchison
• Inventors: Mitchison, Timothy J., Yuan, Junying, Degterev, Alexei
• Granted Patent: US 6,706,766 B2
• Time in Patent Office: Days
• US Class Current: 514/622
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

Abstract

The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.

Claims

1. A method for treating a condition in a subject, said method comprising administering to said subject a chemical compound having the formula:

2. The method of claim 1, wherein each of R₁, R₄, and R₅ is chlorine;

R₂ is bromine; and

R₃ is hydrogen.

3. The method of claim 1, wherein each of R₁, R₄, and R₅ is chlorine;

R₂ is iodine; and

R₃ is hydrogen.

4. The method of claim 1, wherein each of R₁and R₂ is iodine;

each R₄ and R₅ is chlorine; and

R₃ is hydrogen.

5. The method of claim 1, wherein said condition is cancer.

6. The method of claim 5, wherein said condition is selected from the group consisting of prostate cancer, breast cancer, gastrointestinal cancer, non-small cell lung cancer, colon cancer, melanoma, ovarian cancer, stomach cancer, a brain tumor, a leukemia, a lymphoma, or a carcinoma.

7. The method of claim 1, wherein said subject is a mammal.

8. The method of claim 7, wherein said subject is a human.

9. The method of claim 7, wherein said subject is a rodent.

10. The method of claim 1, wherein said compound is substantially pure.

11. The method of claim 1, wherein said compound is in a pharmaceutically acceptable carrier.