Substituted alcohols useful in treatment of Alzheimer's disease
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Abstract
The invention relates to substituted alcohol compounds of the formula (I):
wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are useful in the treatment or prevention of Alzheimer'"'"'s disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer'"'"'s sufferers.
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10 Claims
- 1. A compound of the formula I:
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10. A compound selected from the group consisting of:
Specification