Intelligent brain pacemaker for real-time monitoring and controlling of epileptic seizures
First Claim
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1. An intelligent brain pacemaker for a mammal having a cranial nerve not associated with an autonomic function comprising:
- (a) one or more electrodes adapted to acquire field potential measurements indicative of a mammal'"'"'s brain activity in real-time;
(b) a seizure detector adapted to detect seizure-related brain activity of a mammal in real-time, the seizure detector being electrically connected to the one or more electrodes;
(c) one or more nerve stimulators adapted to provide electrical stimulation to a mammal'"'"'s cranial nerve not associated with an autonomic function, to terminate or ameliorate the seizure, the one or more nerve simulators being electrically connected to the seizure detector; and
(d) a power source for providing power to the intelligent brain pacemaker.
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Abstract
An intelligent brain pace maker for detecting and ameliorating epileptic seizures is disclosed. A method for detecting and ameliorating epileptic seizures is also disclosed. Further, a method of increasing the time interval between epileptic seizures is disclosed.
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Citations
87 Claims
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1. An intelligent brain pacemaker for a mammal having a cranial nerve not associated with an autonomic function comprising:
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(a) one or more electrodes adapted to acquire field potential measurements indicative of a mammal'"'"'s brain activity in real-time;
(b) a seizure detector adapted to detect seizure-related brain activity of a mammal in real-time, the seizure detector being electrically connected to the one or more electrodes;
(c) one or more nerve stimulators adapted to provide electrical stimulation to a mammal'"'"'s cranial nerve not associated with an autonomic function, to terminate or ameliorate the seizure, the one or more nerve simulators being electrically connected to the seizure detector; and
(d) a power source for providing power to the intelligent brain pacemaker. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method of detecting and ameliorating a seizure, in a mammal having a cranial nerve not associated with an autonomic function, the method comprising:
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(a) acquiring field potential data indicative of a subject'"'"'s electrical brain activity in real-time;
(b) analyzing the field potential data to identify seizure-related brain activity;
(c) electrically stimulating a cranial nerve not associated with an autonomic function of the subject, if seizure-related brain activity is identified; and
(d) removing the stimulation when seizure-related brain activity is not detected, whereby a seizure is detected and ameliorated. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A method of increasing the time between epileptic seizures, the method comprising:
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(a) acquiring field potential data from the brain of a subject;
(b) analyzing the field potential data to identify the presence of an epileptic seizure in a subject;
(c) electrically stimulating a cranial nerve not associated with an autonomic function of the subject when an epileptic seizure is identified; and
(d) repeating steps (a) through (c), whereby the time between seizures is increased. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87)
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Specification