Device and method for in vitro determination of analyte concentrations within body fluids
First Claim
1. A method for determining a concentration of an analyte in a body fluid, said method comprising:
- collecting a sample of a body fluid having less than about 0.5 μ
L in total volume;
holding said sample in a nonflowing manner; and
using optical transmission spectroscopy to determine said concentration, without the use of a reagent.
8 Assignments
0 Petitions
Accused Products
Abstract
A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
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Citations
96 Claims
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1. A method for determining a concentration of an analyte in a body fluid, said method comprising:
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collecting a sample of a body fluid having less than about 0.5 μ
L in total volume;
holding said sample in a nonflowing manner; and
using optical transmission spectroscopy to determine said concentration, without the use of a reagent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for determining a concentration of an analyte in a body fluid, said method comprising:
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collecting a sample of body fluid of about 0.5 μ
L or less;
filling a chamber of a sample element with at least a portion of said sample;
holding said sample within said chamber in a non-flowing manner; and
determining said concentration of said analyte in said sample using a reagentless technique. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A method for determining a concentration of an analyte in a body fluid, said method comprising:
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creating an unassisted flow of said body fluid from a patient;
transporting a sample comprising about 0.5 μ
L or less of said body fluid into a chamber of a sample element so that at least some of said sample is adjacent to a window of said sample element;
holding said sample in a non-flowing manner within said chamber of said sample element; and
determining said concentration of said analyte in said body fluid from said sample transported into said sample element without causing said sample to react with a reagent. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
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67. A sample element for use in determining a concentration of an analyte in a body fluid of a patient, said sample element comprising:
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a sample extractor configured to cause a flow of body fluid from a site on said patient; and
a chamber near an operating path of said sample extractor, said chamber defined by at least one inner surface, all of said at least one inner surface comprising a material which is inert with respect to said body fluid, said chamber configured to hold no more than 0.5 μ
L of said body fluid;
wherein, when the patient is lanced with said sample extractor, the body fluid flows from the lanced site into said chamber without displacement of said chamber. - View Dependent Claims (68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79)
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80. A method for determining a concentration of an analyte in a body fluid of an animal, said method comprising:
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causing a flow of body fluid from a site on said animal using a sample extractor having an operating path near a chamber, said chamber defined by at least one inner surface, all of said at least one inner surface comprising a material which is inert with respect to said body fluid; and
collecting at least a portion of said body fluid in said chamber without displacement of said chamber, said chamber being configured to hold at most 0.5 μ
L of said body fluid. - View Dependent Claims (81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92)
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93. A sample element for use in determining a concentration of an analyte in a body fluid of a patient, said sample element comprising:
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a sample extractor configured to cause a flow of body fluid from a site on said patient; and
a chamber near an operating path of said sample extractor, said chamber being inert with respect to said body fluid, said chamber configured to hold no more 0.5 μ
L of said body fluid;
wherein, when the patient is lanced with said sample extractor, the body fluid flows from the lanced site into said chamber without displacement of said chamber. - View Dependent Claims (94)
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95. A sample element for use in determining a concentration of an analyte in a body fluid of a patient, said sample element comprising:
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a sample extractor configured to cause a flow of body fluid from a site on said patient; and
a reagentless chamber near an operating path of said sample extractor, said chamber configured to hold no more than 0.5 μ
L of said body fluid;
wherein, when the patient is lanced with said sample extractor, the body fluid flows from the lanced site into said chamber without displacement of said chamber. - View Dependent Claims (96)
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Specification