Kits for embolizing vascular sites
First Claim
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1. A composition comprising:
- (a) a biocompatible polymer;
(b) a biocompatible contrast agent; and
(c) a biocompatible solvent which solubilizes said biocompatible polymer wherein sufficient amounts of said polymer are employed in said composition such that, upon delivery to a vascular site, a polymer precipitate forms which embolizes said vasculare site; and
farther wherein the viscosity of said composition is at least about 150 cSt at 40°
C.
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Abstract
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
37 Citations
37 Claims
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1. A composition comprising:
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(a) a biocompatible polymer;
(b) a biocompatible contrast agent; and
(c) a biocompatible solvent which solubilizes said biocompatible polymer wherein sufficient amounts of said polymer are employed in said composition such that, upon delivery to a vascular site, a polymer precipitate forms which embolizes said vasculare site; and
farther wherein the viscosity of said composition is at least about 150 cSt at 40°
C. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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2. A composition comprising:
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(a) a biocompatible polymer at a concentration of from about 2 to 50 weight percent;
(b) a biocompatible contrast agent at a concentration of from about 10 to about 40 weight percent; and
(c) a biocompatible solvent from about 10 to 88 weight percent wherein the weight percents of the biocompatible polymer, contrast agent and biocompatible solvent are based on the total weight of the complete composition; and
further wherein the composition has a viscosity of at least about 150 cSt at 40°
C.
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19. A method for enhancing the formation of a solid, non-migratory coherent mass at a selected vascular site of a mammal which method comprises:
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(a) placing a delivery device having an ejection port at a selected vascular site in a mammal;
(b) delivering through the ejection port of the delivery device a composition comprising a biocompatible polymer, a biocompatible solvent and optionally a contrast agent wherein the viscosity of the composition is at least about 150 cSt at 40°
C. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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Specification