Poly(ethylene oxide) coated surfaces
First Claim
1. A method for the fabrication of a hydrophilic coating on the surface of a hydrophobic material, the method comprising:
- a) contacting the surface of a hydrophobic material with a monomer comprising an unsaturated group which is capable of reacting with the surface to enhance the hydrophilicity of the surface;
b) reacting the monomer with the surface, thereby to enhance the hydrophilicity of the surface; and
c) attaching poly(ethylene oxide) molecules to the hydrophilic surface of the support material, after step b), thereby to form a poly(ethylene oxide) coating on the surface.
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Accused Products
Abstract
Methods are provided for the fabrication of hydrophilic coatings on hydrophobic surfaces. In one embodiment, a polyethylene oxide (PEO) coating is fabricated on the surface of a polymeric material by contacting the surface with a methacrylic acid or acrylic acid monomer. The monomer first is reacted, for example by irradiation with an electron beam, to polymerize and covalently attach the monomer to the surface, to improve the hydrophilicity of the polymeric material. A coating of PEO molecules is subsequently attached to the polymer surface by hydrogen bond complexation. The PEO coating then may be covalently grafted onto the surface, for example, by irradiation grafting with an electron beam. The covalent grafting of a coating of the methacrylic or acrylic monomers to the surface greatly improves the wettability of the surface, and facilitates the covalent or non-covalent attachment of a coating of PEO to the polymer surface. Thus, hydrophilic PEO coatings can be fabricated on hydrophobic polymer surfaces, to improve the biocompatibility and other properties of the polymer surfaces.
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Citations
33 Claims
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1. A method for the fabrication of a hydrophilic coating on the surface of a hydrophobic material, the method comprising:
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a) contacting the surface of a hydrophobic material with a monomer comprising an unsaturated group which is capable of reacting with the surface to enhance the hydrophilicity of the surface;
b) reacting the monomer with the surface, thereby to enhance the hydrophilicity of the surface; and
c) attaching poly(ethylene oxide) molecules to the hydrophilic surface of the support material, after step b), thereby to form a poly(ethylene oxide) coating on the surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A hydrophobic material comprising a hydrophilic coating on a surface thereof, wherein the hydrophilic coating comprises a first layer of monomers comprising an unsaturated group covalently grafted to the surface and at least partially polymerized, and a second layer of poly(ethylene oxide) (“
- PEO”
) molecules grafted to the first layer. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
- PEO”
Specification