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Fluorescent dye

  • US 20030088109A1
  • Filed: 02/28/2002
  • Published: 05/08/2003
  • Est. Priority Date: 02/28/2001
  • Status: Active Grant
First Claim
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1. A fluorescent cyanine dye having the formula:

  • T1(—

    CH═

    )n1A (—

    CH═

    )n2T2wherein;

    n≧

    1 and n1 is the same as or different from n2;

    A comprises the formula;

    wherein;

    X1 and Y1 are selected from the group consisting of C(CH3)2, CH═

    CH, O, N, S, Se and Te and either X1 or Y1 is N;

    X2 and Y2 are selected from the group consisting of C(CH3)2, CH═

    CH, O, N, S, Se and Te and either X2 or Y2 is N;

    or A comprises the formula;

    wherein;

    Z1 and Y1 are selected from the group consisting of C(CH3)2, CH═

    CH, O, N, S, Se and Te and either Z1 or Y1 is N;

    Z2 and Y2 are selected from the group consisting of C(CH3)2, CH═

    CH, O, N, S, Se and Te and either Z2 or Y2 is N; and

    wherein a and b are 0 or 1, and a+b=1; and

    where X, Y or Z is N, R2 and R3 are substituents on N and are the same or different and are selected from the group consisting of H, methyl, ethyl, C(CH3)2 and (CH2)qV, wherein q is an integer from 1 to 25 and V is a reactive group or H; and

    wherein;

    T1 and T2 are the same or different and have the formula;

    wherein;

    Q is selected from the group consisting of O, S, CH2, (CH═

    CH) and C(CH3)2;

    R1 and R4 are the same or different and are selected from the group consisting of H, methyl, ethyl and (CH2)qV, wherein q is an integer from 1 to 25 and V is a reactive group or H;

    each of W1-8 is the same or different and may be H or a hydrophilic moiety;

    at least one occurrence of W is a hydrophilic moiety; and

    wherein at least one of R1-R4 has a reactive group.

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