Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
First Claim
1. A controlled drug delivery device, adapted for whole implantation, the device comprising:
- a housing defining a reservoir, the reservoir containing a formulation comprising a drug selected from the group consisting of fentanyl or a fentanyl congener, wherein the drug is present in an amount sufficient for treatment of pain in a subject for a period of at least about 3 days;
a pump operatively connected to the housing; and
a thermal expansion element comprising an inlet, a thermal expansion channel adapted to contain a volume of formulation associated with thermal expansion, and an outlet;
wherein in use, the inlet, thermal expansion channel, and outlet define a flow pathway from the reservoir and out of the device such that actuation of the pump effects movement of formulation through the flow pathway.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.
99 Citations
27 Claims
-
1. A controlled drug delivery device, adapted for whole implantation, the device comprising:
-
a housing defining a reservoir, the reservoir containing a formulation comprising a drug selected from the group consisting of fentanyl or a fentanyl congener, wherein the drug is present in an amount sufficient for treatment of pain in a subject for a period of at least about 3 days;
a pump operatively connected to the housing; and
a thermal expansion element comprising an inlet, a thermal expansion channel adapted to contain a volume of formulation associated with thermal expansion, and an outlet;
wherein in use, the inlet, thermal expansion channel, and outlet define a flow pathway from the reservoir and out of the device such that actuation of the pump effects movement of formulation through the flow pathway. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. A controlled drug delivery device, adapted for whole implantation, the device comprising:
-
a housing defining a reservoir, the reservoir containing a formulation comprising sufentanil in an amount sufficient for treatment of pain in a subject for a period of at least about 3 days;
a pump operatively connected to the housing; and
a thermal expansion element comprising an inlet, a thermal expansion channel adapted to contain a volume of formulation associated with thermal expansion, and a delivery outlet;
wherein in use, the inlet, thermal expansion channel, and outlet define a flow pathway from the reservoir and out of the device such that actuation of the pump effects movement of formulation through the flow pathway. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27)
-
Specification