Surgical system for tissue fixation

• US 20030088252A1
• Filed: 12/17/2002
• Published: 05/08/2003
• Est. Priority Date: 09/30/1999
• Status: Abandoned Application

• Current Assignee: Auvo Kaikkonen, Harri Happonen, Hermann Sailer, Olli Karhi, Pertti Tormala, Piet E. Haers, Riitta Suuronen, Timo Waris
• Original Assignee: Auvo Kaikkonen, Harri Happonen, Hermann Sailer, Olli Karhi, Pertti Tormala, Piet E. Haers, Riitta Suuronen, Timo Waris
• Inventors: Haers, Piet E., Tormala, Pertti, Waris, Timo, Sailer, Hermann, Kaikkonen, Auvo, Happonen, Harri, Karhi, Olli, Suuronen, Riitta
• Application Number:
  US10/320,629
• Publication Number:
  US 20030088252A1
• Time in Patent Office: Days
• US Class Current: 606/76
• CPC Class Codes: A61B 17/68 Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin bone staples A61B17/0642
• CPC Class Codes: A61B 17/92 Impactors or extractors, e.g. for removing intramedullary devices insertion or extraction of artificial joints A61F2/4603

Abstract

A surgical tissue fixation system is described, including: (1) a bioabsorbable tissue fixation plate having optionally a plurality of through-holes arranged in alternating relation along the plate; (2) bioabsorbable fasteners adapted for insertion into the through-holes to secure the plate to underlying bodily tissue or bone; and (3) an installation instrument which triggers (strikes or shoots) fasteners one after one, in rapid succession, into the through-holes made through the plate and into the underlying bodily tissue or bone, which also optionally includes drillholes.

Claims

1. A synthetic bioabsorbable drug-delivery material comprising:

a synthetic bioabsorbable polymeric matrix;

an antibiotic phase dispersed into said polymeric matrix; and

antibacterial, bioabsorbable, bioactive glass dispersed into said polymeric matrix for the promotion of bone growth.

2. The drug delivery material of claim 1, wherein the material is in the form of microspheres, spheres, capsules, tablets, pearls, pearls in string, beads, membranes, films, fibers, filaments, threads, cords or knitted or woven fiber fabrics.

3. The drug delivery material of claim 1, wherein said antibiotic phase comprises from 1 to 20 weight percent of said material.

4. The drug delivery material of claim 1, wherein at least a portion of said material is porous.

5. The drug delivery material of claim 4, wherein the surface of said material is porous.

6. The drug delivery material of claim 1, wherein said antibiotic phase is released from said material for a period of at least 4 weeks in in vivo conditions.

7. The drug delivery material of claim 6, wherein said bioactive glass is released from said material for a period of at least 4 weeks in in vivo conditions.

8. The drug delivery material of claim 6 wherein said antibiotic phase is released at a levelof at least 2 mg/l after 4 weeks in in vivo conditions.

9. The drug delivery material of claim 6 wherein said antibiotic phase is released at a level of at least 10 mg/l after 4 weeks in in vivo conditions.

10. The drug delivery material of claim 1 wherein said bioactive glass is in the form of fibers.

11. The drug delivery material of claim 10 wherein said fibers reinforce said material.

12. The drug delivery material of claim 1, wherein the material is self-reinforced through solid state deformation.

13. The drug delivery material of claim 9 wherein said antibiotic phase comprises ciprofloxazine.

14. A surgical implant comprising the material of claim 1.

15. The implant of claim 14, wherein the implant is in the form of a pin, screw, plate, tack, intramedullary nail, bolt, suture anchor, tissue anchor, interference screw, arrow, or wedge.

16. The implant of claim 14, wherein said material is a coating on the surface of said implant.

17. A method of treating osteomyelitis or bone infection in a bone comprising:

providing a synthetic bioabsorbable drug-delivery material comprising;

a synthetic bioabsorbable polymeric matrix;

an antibiotic phase dispersed into said polymeric matrix; and

antibacterial, bioabsorbable, bioactive glass dispersed into said polymeric matrix for the promotion of bone growth; and

applying said material to said bone.

18. The method of claim 17 wherein said antibiotic phase comprises from 1 to 20 weight percent of said material and said antibiotic phase is released at a levelof at least 2 mg/l after 4 weeks in in vivo conditions.