Actuator nozzle for metered dose inhaler
First Claim
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1. An actuator for a metered dose inhaler containing a liquefied propellant and a medicament, said actuator comprising:
- a nozzle block having a fluid flow path extending therethrough, said fluid flow path defined by an internal chamber having an inlet and an outlet;
said outlet being defined in a portion of said nozzle block and comprising an exit channel extending therethrough, wherein said exit channel has a narrow portion wherein the diameter of the channel is 0.3 mm or less, said narrow portion being 0.5 mm or less in length;
said narrow portion optionally including a constriction, said constriction having a diameter of less than 0.3 mm.
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Abstract
An actuator for a metered dose inhaler containing a liquefied propellant and a medicament. The actuator comprises a nozzle block having a fluid flow path extending therethrough, the fluid flow path defined by an internal chamber having an inlet and an outlet; the outlet being defined in a portion of said nozzle block and comprising an exit channel extending therethrough. The exit channel has a narrow portion wherein the diameter of the channel is 0.3 mm or less, the narrow portion being 0.5 mm or less in length; and the narrow portion optionally including a constriction having a diameter of less than 0.3 mm.
77 Citations
23 Claims
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1. An actuator for a metered dose inhaler containing a liquefied propellant and a medicament, said actuator comprising:
- a nozzle block having a fluid flow path extending therethrough, said fluid flow path defined by an internal chamber having an inlet and an outlet;
said outlet being defined in a portion of said nozzle block and comprising an exit channel extending therethrough, wherein said exit channel has a narrow portion wherein the diameter of the channel is 0.3 mm or less, said narrow portion being 0.5 mm or less in length;
said narrow portion optionally including a constriction, said constriction having a diameter of less than 0.3 mm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 23)
- a nozzle block having a fluid flow path extending therethrough, said fluid flow path defined by an internal chamber having an inlet and an outlet;
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21. A method for generating a material plume from a nozzle comprising the steps of:
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a. providing an actuator for a metered dose inhaler comprising;
a nozzle block having a fluid flow path extending therethrough, said fluid flow path defined by an internal chamber having an inlet and an outlet;
said outlet being defined in a portion of said nozzle block and comprising an exit channel extending therethrough;
wherein said exit channel has a narrow portion wherein the diameter of the channel is 0.3 mm or less, said narrow portion being 0.5 mm or less in length;
said narrow portion optionally including a constriction, said constriction having a diameter of less than 0.3 mm;
b. introducing a metered dose of fluid containing a low boiling point propellant into said inlet;
c. expelling said fluid from said outlet in particulate form.
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22. A method for the treatment, prophylaxis or diagnosis of a condition or disease in a patient comprising:
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a. providing a metered dose inhaler comprising;
1. a canister containing a medicament in suspension or solution with a low boiling point fluid propellant, said canister possessing a metering valve for metering a dose of said suspension or solution, and hollow valve stem for transferring said metered dose from said metering valve, and 2. an actuator comprising;
a nozzle block having a fluid flow path extending therethrough, said fluid flow path defined by an internal chamber having an inlet and an outlet;
said outlet being defined in a portion of said nozzle block and comprising an exit channel extending therethrough;
wherein said exit channel has a narrow portion wherein the diameter of the channel is 0.3 mm or less, said narrow portion being 0.5 mm or less in length;
said narrow portion optionally including a constriction, said constriction having a diameter of less than 0.3 mm; and
b. introducing a metered dose of low boiling point propellant fluid into said inlet;
c. ejecting said metered dose from said outlet in particulate form; and
d. delivering said ejected metered dose to the pulmonary system of the patient.
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Specification