Fluidic methods and devices for parallel chemical reactions
First Claim
1. A microfluidic reactor comprising:
- a plurality of flow-through reaction cells for parallel chemical reactions, each reaction cell comprising;
i. at least one illumination chamber, and ii. at least one reaction chamber, wherein the illumination chamber and the reaction chamber are in flow communication and are spatially separated in the reaction cell.
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Abstract
Fluidic methods and devices for conducting parallel chemical reactions are disclosed. The methods are based on the use of in situ photogenerated reagents such as photogenerated acids, photogenerated bases, or any other suitable chemical compounds that produce active reagents upon light radiation. The present invention describes devices and methods for performing a large number of parallel chemical reactions without the use of a large number of valves, pumps, and other complicated fluidic components. The present invention provides microfluidic devices that contain a plurality of microscopic vessels for carrying out discrete chemical reactions. Other applications may include the preparation of microarrays of DNA and RNA oligonucleotides, peptides, oligosacchrides, phospholipids and other biopolymers on a substrate surface for assessing gene sequence information, screening for biological and chemical activities, identifying intermolecular complex formations, and determining structural features of molecular complexes.
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Citations
159 Claims
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1. A microfluidic reactor comprising:
a plurality of flow-through reaction cells for parallel chemical reactions, each reaction cell comprising;
i. at least one illumination chamber, and ii. at least one reaction chamber, wherein the illumination chamber and the reaction chamber are in flow communication and are spatially separated in the reaction cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 151, 153, 155, 157)
- 50. A microfluidic reactor comprising a plurality of flow-through photoillumination reaction cells for parallel chemical reactions in fluid communication with at least one inlet channel and at least one outlet channel.
- 100. A microfluidic reactor comprising at least one microfluidic template and window plates attached to the template, the microfluidic template and window plates defining a plurality of reaction cells which provide for flow of liquid solution through the cells for parallel chemical reactions, each reaction cell comprising a first chamber in fluid communication with but spatially separated from a second chamber, the first chamber being adapted to be an illumination chamber, and the second chamber being adapted to be a reaction chamber for reaction of photo-generated products in the first chamber.
- 110. A microfluidic reactor comprising at least one microfluidic template and window plates attached to the template, the reactor providing at least one inlet channel, at least one outlet channel, and distribution channels, and a plurality of liquid flow-through photoillumination reaction cells for parallel chemical reactions.
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120. A microfluidic reactor comprising:
a plurality of flow-through reaction cells in fluid communication with each other via distribution channels for parallel chemical reactions, each reaction cell comprising;
i. at least one illumination chamber, and ii. at least one reaction chamber, wherein the illumination chamber and the reaction chamber are in flow communication and overlap with each other in the reaction cell. - View Dependent Claims (121, 122, 123, 124, 125, 126, 127, 128, 129)
- 130. A high-density flowthrough multi-cell microfluidic reactor comprising a microfluidic template, at least one inlet channel, at least one outlet channel, and a plurality of flow through reaction cells for parallel chemical reactions, wherein the inlet channel and outlet channel are imbedded in the mid-section of the microfluidic template.
- 135. A microfluidic reactor comprising a microfluidic template, a back plate attached to the template, and a window plate attached to the template, wherein the reactor comprises a plurality of flow-through reaction cells in fluid communication with an inlet channel and an outlet channel for parallel chemical reactions, wherein the inlet channel and the outlet channel are located between the back plate and the microfluidic template.
- 140. A microfluidic reactor comprising a plurality of flow-through photoillumination reaction cells for parallel chemical reactions in fluid communication with at least one inlet channel and at least one outlet channel, wherein the reaction cells are connected to fluid distribution channels in parallel which comprise a through-hole at their end so that fluid can flow through the channel without passing through the reaction cells.
- 145. A microfluidic reactor comprising a plurality of flow-through photoillumination reaction cells for parallel chemical reactions in fluid communication with at least one inlet channel and at least one outlet channel, wherein the reaction cells are connected in parallel with fluid distribution channels, wherein each reaction cell has a separate outlet channel which allows for individual collection of effluent from each reaction cell.
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150. A microfluidic reactor adapted for in situ use of photogenerated reagents, wherein the reactor comprises an inlet channel, an illumination chamber, a connection channel, a reaction chamber, and an outlet channel, wherein the illumination chamber connects with the inlet channel, the connection channel connects the illumination chamber and the reaction chamber, and the outlet channel connects with the reaction chamber.
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159. A method for enhancing parallel photochemical reactivity in a microfluidic reactor having a plurality of isolated reaction cells, said method comprising the step of providing spatially separated or overlapping illumination and reaction chambers in each reaction cell.
Specification