Flow-thru chip cartridge, chip holder, system & method thereof

• US 20030091477A1
• Filed: 07/02/2002
• Published: 05/15/2003
• Est. Priority Date: 12/22/1999
• Status: Abandoned Application

• Current Assignee: Eric A. Paul, Matthew Torres
• Original Assignee: Eric A. Paul, Matthew Torres
• Inventors: Paul, Eric A., Torres, Matthew
• Application Number:
  US10/186,625
• Publication Number:
  US 20030091477A1
• Time in Patent Office: Days
• US Class Current: 422/400
• CPC Class Codes: B01J 2219/00 Chemical, physical or physico-chemical processes in general; Their relevant apparatus
• CPC Class Codes: B01J 2219/00274 Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0877 Flow chambers
• CPC Class Codes: B01L 2300/18 Means for temperature control
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 2400/06 Valves, specific forms thereof
• CPC Class Codes: B01L 2400/0622 distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 9/527 for microfluidic devices, e.g. used for lab-on-a-chip
• CPC Class Codes: G01N 2021/0346 Capillary cells; Microcells
• CPC Class Codes: G01N 21/05 Flow-through cuvettes G01N21/09 takes precedence; handling fluid samples G01N1/10
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00

Abstract

A system for performing hybridization assays is disclosed which has a cartridge for housing an array device. The cartridge may include a test fluid chamber for facilitating a substantially uniform flow of a test fluid mixture through the flow through device, and may include a fluidics station to deliver the test fluid mixture to the cartridge. The cartridge has a plurality of channels to receive fluids used in the performance of hybridization assays and to keep them separate, if desired.

Claims

1. A cartridge for housing an array device comprising a plurality of channels for receiving different fluids.

2. A cartridge according to claim 1 where said plurality of channels receive fluids selected from test fluid and assay reagent fluid.

3. A cartridge according to claim 1 wherein said plurality of channels prevent the different fluids from mixing while in the cartridge.

4. A cartridge according to claim 1 wherein said array device is a flow through device.

5. A method for using an array device for the detection of at least one reaction comprising employing a cartridge for housing the array device comprising a plurality of channels for receiving different fluids and introducing a different fluid into each of said plurality of channels.

6. A method according to claim 5 wherein said at least one reaction is a hybridization reaction.

7. A method according to claim 5 wherein said plurality of channels receive fluids selected from test fluid and assay reagent fluid.

8. A method according to claim 5 wherein said plurality of channels prevent the different fluids from mixing while in the cartridge.

9. A method according to claim 5 wherein said array device is a flow through device.