Method and device for producing compression coated tablets
First Claim
1. A process for production of a tablet comprising the steps of:
- a) placing core material into a cup in a die, wherein the cup is comprised of coating material, and b) pressing the core material into the cup using an upper punch in an extended configuration, and c) compacting the cup using an upper punch in a retracted configuration, thereby forming the tablet.
1 Assignment
0 Petitions
Accused Products
Abstract
A method is disclosed for producing coated compressed tablets, using at least one upper punch. The upper punch can be a single punch with a hollow shaft containing a movable rod with a tip that is extended or retracted as the rod moves within the shaft. Alternatively, two solid upper punches are used, one with an extended tip and the other with a retracted tip. An upper punch with an extended tip is designed to produce cup-shaped compacts of excipient and/or polymeric tablet coating material, when inserted into the die. Core material is inserted into each cup. Additional coating material is then placed on top of the cup and core, within the die, and compressed with an upper punch with a retracted tip. The method and device of the present invention enables one to produce tablets from poorly compactable substances.
46 Citations
47 Claims
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1. A process for production of a tablet comprising the steps of:
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a) placing core material into a cup in a die, wherein the cup is comprised of coating material, and b) pressing the core material into the cup using an upper punch in an extended configuration, and c) compacting the cup using an upper punch in a retracted configuration, thereby forming the tablet. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An upper punch for production of a tablet comprising:
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an outer hollow punch with an outer tip at one end and an outer head at another end, walls of the outer hollow punch defining a hollow shaft extending from the outer tip through the outer hollow punch to the outer head; and
a core rod contained within the hollow shaft, the rod having a rod tip at an end closest to the outer tip and a rod head at an end closest to the outer head, the core rod being moveable within the shaft. - View Dependent Claims (15)
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16. A tablet press comprising an upper punch comprising:
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an outer hollow punch with an outer tip at one end and an outer head at another end, walls of the outer hollow punch defining a hollow shaft extending from the outer tip through the outer hollow punch to the outer head; and
a core rod contained within the hollow shaft, the rod having a rod tip at an end closest to the outer tip and a rod head at an end closest to the outer head, wherein movement of the core rod within the shaft alters the configuration of the upper punch from an extended configuration to a retracted configuration. - View Dependent Claims (17, 18, 19, 20)
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21. A tablet manufactured according to a process comprising the steps of:
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a) placing core material into a cup comprised of coating in a die, wherein the cup is comprised of coating material, and b) pressing the core material into the cup using an upper punch in an extended configuration with an extended tip, and c) compacting the cup using an upper punch in an extended configuration with a retracted tip, thereby forming a tablet comprising a core and a coating. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A process for production of a tablet comprising the steps of:
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a) forming a cup of core material by pressing the core material in a die using an upper punch in an extended configuration;
b) placing core material into the cup in the die, and c) pressing the core material into the cup using an upper punch in an extended configuration, and d) compacting the cup and core material using an upper punch in a retracted configuration, thereby forming the tablet. - View Dependent Claims (43, 44, 45, 46, 47)
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Specification