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Interaction of NMDA receptor with protein tyrosine phosphatase

  • US 20030092071A1
  • Filed: 09/18/2002
  • Published: 05/15/2003
  • Est. Priority Date: 02/01/2000
  • Status: Abandoned Application
First Claim
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1. A method for identifying a modulator of N-methyl-D-aspartate receptor (NMDA-R) signaling activity, comprising detecting the ability of an agent to modulate the phosphatase activity of a protein tyrosine phosphatase L1 (PTPL1) on a substrate or to modulate the binding of the PTP to NMDA-R, thereby identifying the modulator, wherein the PTPL1 is capable of directly or indirectly dephosphorylating NMDA-R.

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