Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
First Claim
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1. A method for coating a colorimetric resonant biosensor surface with aldehyde binding sites, the method comprising:
- (a) activating the surface with amine groups to form an amine-activated surface; and
(b) adding an aldehyde solution comprising cyanoborohydride to the amine-activated surface, whereby the surface is coated with aldehyde binding sites.
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Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. Specifically, the invention herein provides a robust and reproducible method for coating sensor surfaces with aldehyde functional groups as well as methods for testing the efficiency and completeness of the coating process.
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23 Claims
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1. A method for coating a colorimetric resonant biosensor surface with aldehyde binding sites, the method comprising:
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(a) activating the surface with amine groups to form an amine-activated surface; and
(b) adding an aldehyde solution comprising cyanoborohydride to the amine-activated surface, whereby the surface is coated with aldehyde binding sites. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification