Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic
First Claim
1. A multilayer dosage form for oral administration comprising:
- at least one layer comprising an opioid analgesic, a non-opioid analgesic, and a sustained release mechanism; and
at least another layer comprising an opioid analgesic and a non-opioid analgesic.
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Accused Products
Abstract
The present invention relates to new and useful oral tablet compositions which include an immediate release portion having an opioid analgesic and a non-opioid analgesic, providing for a rapid onset of therapeutic effect, and a sustained release portion of an opioid analgesic and a non-opioid analgesic, providing for a relatively longer duration of therapeutic effect. A multilayer oral dosage form containing a sustained release layer, which includes oxycodone and APAP, hydrocodone and APAP, or oxymorphone and APAP, and an immediate release layer containing the same active ingredients as the sustained release layer, is also disclosed. Also disclosed are oral tablet compositions, containing a sustained release core, which includes oxycodone and APAP, hydrocodone and APAP, or oxymorphone and APAP, and an immediate release coating containing the same active ingredients as the sustained release core, are also disclosed. In addition, methods of making and using such oral tablet compositions are disclosed.
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Citations
29 Claims
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1. A multilayer dosage form for oral administration comprising:
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at least one layer comprising an opioid analgesic, a non-opioid analgesic, and a sustained release mechanism; and
at least another layer comprising an opioid analgesic and a non-opioid analgesic. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 29)
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12. A method of making a multilayer oral dosage form comprising:
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forming at least one layer comprising an opioid analgesic, a non-opioid analgesic, and a sustained release mechanism and compressing it; and
,forming at least one additional layer comprising an opioid analgesic and a non-opioid analgesic and compressing it over the compressed first layer, or vice versa. - View Dependent Claims (13, 14)
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15. A dosage form for oral administration comprising:
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a sustained release core layer comprising an opioid analgesic, a non-opioid analgesic, and a sustained release mechanism; and
,a coating layer comprising an opioid analgesic and a non-opioid analgesic. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of making an oral dosage form comprising:
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forming a core tablet comprising an opioid analgesic, a non-opioid analgesic, and a sustained release mechanism and compressing it; and
,forming a coating over the core tablet comprising an opioid analgesic and a non opioid analgesic with an immediate release mechanism. - View Dependent Claims (27, 28)
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Specification