Biodegradable injectable implants and related methods of manufacture and use
First Claim
1. A biodegradable, injectable implant comprising glycolic acid and particles comprised of a polymer comprising lactic acid repeats units, wherein the particles have a diameter of from about 20μ
- to about 120μ
.
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Accused Products
Abstract
This invention is directed to the field of medical implants, and more specifically to biodegradable injectable implants and their methods of manufacture and use. The injectable implants disclosed herein comprise glycolic acid and bio-compatible/bio-absorbable polymeric particles containing a polymer of lactic acid. The particles are small enough to be injected through a needle but large enough to avoid engulfment by macrophages. The injectables of this invention may be in a pre-activated solid form or an activated form (e.g., injectable suspension or emulsion).
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Citations
88 Claims
- 1. A biodegradable, injectable implant comprising glycolic acid and particles comprised of a polymer comprising lactic acid repeats units, wherein the particles have a diameter of from about 20μ
- 43. A biodegradable, injectable implant comprising glycolic acid and particles comprised of polylactic acid, wherein the particles have a mean diameter of from about 40μ
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70. A biodegradable, injectable implant comprising:
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a) glycolic acid;
b) particles of polylactic acid, wherein the particles have a mean diameter of from about 40μ
to about 80μ
;
c) a gelling agent;
d) a surfactant;
e) a cryoprotecting agent; and
f) a buffering agent, wherein the implant comprises an aqueous suspension of particles of the polylactic acid. - View Dependent Claims (71, 72, 73, 74, 75, 76, 77)
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78. A method of making a biodegradable, injectable implant comprising:
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a) pulverizing a polymer comprising lactic acid repeat units to a first powder;
b) cold micronizing the first powder to form particles having a mean diameter of from about 40μ
to about 80μ
;
c) forming an emulsion comprising the particles;
d) obtaining a solution which comprises glycolic acid;
e) mixing the emulsion and solution during heating to obtain an aqueous slurry;
f) drying the aqueous slurry to obtain a second powder; and
g) lyophilizing the second powder. - View Dependent Claims (79, 80, 81)
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82. A method for soft tissue augmentation comprising injecting a mammal at an injection site in need of such soft tissue augmentation a bulking agent comprising glycolic acid and polymeric particles comprising lactic acid repeat units, wherein the particles have a mean diameter of from about 40μ
- to about 80μ
. - View Dependent Claims (83, 84, 85, 86, 87)
- to about 80μ
-
88. A method for improving the appearance of a wrinkle on a human comprising injecting glycolic acid into the human at the wrinkle.
Specification