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Complexity management of genomic DNA

  • US 20030096235A1
  • Filed: 07/31/2001
  • Published: 05/22/2003
  • Est. Priority Date: 10/27/1999
  • Status: Active Grant
First Claim
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1. A method of reducing the complexity of a nucleic acid sample comprising:

  • fragmenting the nucleic acid sample using a first and second restriction enzyme to produce fragments;

    ligating adaptors to the fragments; and

    selectively amplifying the fragments that were cut on one end by the first restriction enzyme and on the other end by the second restriction enzyme.

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