Cell substrates and methods of use thereof
First Claim
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1. A cell support useful for the implantation of cells in a subject, said cell support comprising:
- a solid substrate formed from a biologically inert material and having a textured surface portion, said textured surface portion defining a plurality of recessed cavities in said textured surface portion; and
a plurality of live cells deposited on said textured surface portion in said recessed cavities so that said cells are protected from mechanical dislodgment therefrom;
wherein said cells consist essentially of nonembryonic hepatic or pancreatic progenitor cells.
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Abstract
A cell support system useful for the implantation of living cells in a subject comprises a solid substrate, typically formed from a biologically inert material. The substrate has a textured surface portion, with the textured surface portion defining a plurality of recessed cavities therein. A plurality of live cells to be implanted are deposited on the textured surface portion so that the cells (or progeny thereof) are protected from mechanical dislodgment.
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Citations
42 Claims
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1. A cell support useful for the implantation of cells in a subject, said cell support comprising:
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a solid substrate formed from a biologically inert material and having a textured surface portion, said textured surface portion defining a plurality of recessed cavities in said textured surface portion; and
a plurality of live cells deposited on said textured surface portion in said recessed cavities so that said cells are protected from mechanical dislodgment therefrom;
wherein said cells consist essentially of nonembryonic hepatic or pancreatic progenitor cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of implanting cells in a subject, comprising the steps of:
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(a) providing a cell support comprising (i)a solid substrate formed from a biologically inert material and having a textured surface portion, said textured surface portion defining a plurality of recessed cavities in said textured surface portion, and (ii) a plurality of live cells deposited on said textured surface portion in said recessed cavities so that said cells are protected from mechanical dislodgement therefrom, wherein said cells consist essentially of nonembryonic hepatic or pancreatic progenitor cells; and
then(b) implanting said cell support in said subject. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method of making a cell support useful for the implantation of living cells in a subject, said method comprising the steps of:
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(a) providing a solid substrate formed from a biologically inert material and having a textured surface portion, said textured surface portion defining a plurality of recessed cavities in said textured surface portion; and
then(b) depositing a plurality of cells on said textured surface portion in said recessed cavities so that said cells are protected from subsequent mechanical dislodgment therefrom, wherein said cells consist essentially of nonembryonic hepatic or pancreatic progenitor cells. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method for the implantation of cells in a subject, said method comprising the steps of:
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(a) providing a solid substrate formed from a biologically inert material and having a textured surface portion, said textured surface portion defining a plurality of recessed cavities in said textured surface portion; and
then(b) depositing a plurality of live nonembryonic progenitor cells on said textured surface portion in said recessed cavities so that said cells are protected from subsequent mechanical dislodgment therefrom; and
then(c) implanting said solid support in a subject. - View Dependent Claims (38, 39, 40, 41, 42)
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Specification