Instrument
First Claim
1. A method for determining the concentration of a first, medically significant component of a biological fluid or a control, the biological fluid or control including a second component which affects the determination of the concentration of the first component, the method including performing a first measurement on the biological fluid or control which first measurement varies with both the concentration of the first component and at least one of the presence and concentration of the second component, performing a second measurement on the biological fluid or control which second measurement also varies with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component, and removing an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement.
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Accused Products
Abstract
A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the biological fluid or control, which second measurement varies primarily only with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component. The first and second measurements may be made sequentially or simultaneously. The method and apparatus then remove an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement.
108 Citations
58 Claims
- 1. A method for determining the concentration of a first, medically significant component of a biological fluid or a control, the biological fluid or control including a second component which affects the determination of the concentration of the first component, the method including performing a first measurement on the biological fluid or control which first measurement varies with both the concentration of the first component and at least one of the presence and concentration of the second component, performing a second measurement on the biological fluid or control which second measurement also varies with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component, and removing an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement.
- 28. Apparatus for determining the concentration of a first, medically significant component of a biological fluid or a control, the biological fluid or control including a second component which affects the determination of the concentration of the first component, the apparatus including a device for performing a first measurement on the biological fluid or control which first measurement varies with both the concentration of the first component and at least one of the presence and concentration of the second component, performing a second measurement on the biological fluid or control which second measurement varies primarily only with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component, and removing an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement.
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55. A method for substantially concurrently determining the concentrations of first and second medically significant components of a biological fluid or a control during an assay of a sample of the biological fluid or control, the method including developing an equivalent electrical circuit model of a sample of the biological fluid or control and an apparatus for assaying the biological fluid or control, identifying at least a first element of the electrical circuit model, the behavior of which at least first element varies with the concentration of the first component relatively independently of the concentration of the second component, identifying at least a second element of the electrical circuit model, the behavior of which at least second element varies with the concentration of the second component relatively independently of the concentration of the first component, separately assessing the behaviors of the at least first element and the at least second element during the assay, and determining from the separate assessments of the behaviors of the at least first element and the at least second element the concentrations of the first component and the second component.
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56. Apparatus for substantially concurrently determining the concentrations of first and second medically significant components of a sample of a biological fluid or a control during an assay of the sample, the combination of the apparatus for assaying the sample and the sample together characterized by an equivalent electrical circuit model including at least a first element, the behavior of which at least first element varies with the concentration of the first component relatively independently of the concentration of the second component, the equivalent electrical circuit model further including at least a second element, the behavior of which at least second element varies with the concentration of the second component relatively independently of the concentration of the first component, the apparatus including a device for separately assessing the behaviors of the at least first element and the at least second element during the assay, and determining from the separate assessments of the behaviors of the at least first element and the at least second element the concentrations of the first component and the second component.
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57. A method for substantially concurrently determining the concentrations of first and second medically significant components of a biological fluid or a control during an assay of a sample of the biological fluid or control, the method including developing an equivalent electrical circuit model of a sample of the biological fluid or control and an apparatus for assaying the biological fluid or control, identifying at least a first element of the electrical circuit model, the behavior of which at least first element varies with the concentration of the first component relatively independently of the concentration of the second component, identifying at least a second element of the electrical circuit model, the behavior of which at least second element varies with the concentrations of both the first and second components, separately assessing the behaviors of the at least first element and the at least second element during the assay, and determining from the separate assessments of the behaviors of the at least first element and the at least second element the concentrations of the first component and the second component.
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58. Apparatus for substantially concurrently determining the concentrations of first and second medically significant components of a sample of a biological fluid or a control during an assay of the sample, the combination of the apparatus for assaying the sample and the sample together characterized by an equivalent electrical circuit model including at least a first element, the behavior of which at least first element varies with the concentration of the first component relatively independently of the concentration of the second component, the equivalent electrical circuit model further including at least a second element, the behavior of which at least second element varies with the concentrations of both the first and second components, the apparatus including a device for separately assessing the behaviors of the at least first element and the at least second element during the assay, and determining from the separate assessments of the behaviors of the at least first element and the at least second element the concentrations of the first component and the second component.
Specification