Defective adenovirus vectors and use thereof in gene therapy
First Claim
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1. A defective recombinant adenovirus comprising the ITR sequences, a sequence permitting the encapsulation, a heterologous DNA sequence, and in which the E1 gene and at least one of the E2, E4 and L1-L5 genes is non-functional.
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Abstract
Novel adenovirus-derived viral vectors, the preparation thereof, and the use thereof in gene therapy, are disclosed.
53 Citations
30 Claims
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1. A defective recombinant adenovirus comprising
the ITR sequences, a sequence permitting the encapsulation, a heterologous DNA sequence, and in which the E1 gene and at least one of the E2, E4 and L1-L5 genes is non-functional.
Specification