Bioactive surface modifiers for polymers and articles made therefrom
First Claim
1. A bioactive fluoroalkyl surface modifier for use in admixture with a compatible base polymer, said modifier having the general formula
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Abstract
This invention relates to macromolecule modifiers containing biologically active drugs/biomolecules, or precursors thereof, and fluoroligomers; compositions comprising the macromolecules containing the drugs and fluoroligomers in admixture with polymers, particularly biomedical polymers; articles made from the admixtures, particularly medical devices. Specifically, the modifier has the general formula
comprising an oligomeric polymeric segment having a theoretical molecular weight of less than 15,000, and being compatible with said base polymer; wherein
[oligo] is a first oligomeric segment;
[link A] is a second coupling segment linking one [oligo] to another [oligo] within said central portion;
n is 0 to 20;
[fluoro] is a polyfluoro oligomeric group; and
[link B] is a first coupling segment linking said central portion to said [fluoro] through said first coupling segment; and coupled to a bioactive moiety [Bio] or precursor thereof; and
m is 1 to 20.
30 Citations
22 Claims
- 1. A bioactive fluoroalkyl surface modifier for use in admixture with a compatible base polymer, said modifier having the general formula
Specification