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Methods and devices for characterizing duplex nucleic acid molecules

  • US 20030099951A1
  • Filed: 11/21/2001
  • Published: 05/29/2003
  • Est. Priority Date: 11/27/2000
  • Status: Active Grant
First Claim
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1. A method of characterizing a duplex nucleic acid molecule, said method comprising:

  • (a) contacting a conducting fluid medium comprising said duplex nucleic acid with a nanopore;

    (b) applying an electric field to said medium and monitoring current changes through said nanopore resulting from said duplex nucleic acid to obtain a set of observed data values; and

    (c) characterizing said nucleic acid based on said set of observed data values;

    to characterize said duplex nucleic acid molecule.

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