Novel genes, compositions, kits and methods for identification, assessment, prevention, and therapy of breast cancer

• US 20030099974A1
• Filed: 07/18/2002
• Published: 05/29/2003
• Est. Priority Date: 07/18/2001
• Status: Abandoned Application

• Current Assignee: Millennium Pharmaceuticals Incorporated (Takeda Pharmaceutical Company Limited)
• Original Assignee: Millennium Pharmaceuticals Incorporated (Takeda Pharmaceutical Company Limited)
• Inventors: Steinmann, Kathleen, Wang, Youzhen, Lillie, James, Xu, Yongyao
• Application Number:
  US10/198,846
• Publication Number:
  US 20030099974A1
• Time in Patent Office: Days
• US Class Current: 435/6.14
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: G01N 33/57415 of breast

Abstract

The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.

Claims

1. An isolated nucleic acid molecule comprising SEQ ID NO:

1, or a complement thereof.

2. A vector which contains the nucleic acid molecule of claim 1.

3. A host cell which contains the nucleic acid molecule of claim 1.

6. A method for producing a polypeptide comprising culturing the host cell of claim 3 under conditions in which the nucleic acid molecule is expressed.

9. A method for detecting the presence of the nucleic acid molecule of claim 1 in a sample comprising:

a) contacting the sample with a nucleic acid probe or primer which selectively hybridizes to the nucleic acid molecule; and

b) determining whether the nucleic acid probe or primer binds to a nucleic acid molecule in the sample to thereby detect the presence of the nucleic acid molecule of claim 1 in the sample.

10. The method of claim 9, wherein the sample comprises mRNA molecules and is contacted with a nucleic acid probe.

11. The method of claim 9, wherein the sample is isolated from breast tissue.

12. The method of claim 9, wherein the sample is a tumor sample.

13. A kit comprising a compound which selectively hybridizes to the nucleic acid molecule of claim 1.

4. An isolated polypeptide which is encoded by a nucleic acid molecule comprising SEQ ID NO:

1.

5. An antibody which selectively binds to the polypeptide of claim 4.

7. A method for detecting the presence of the polypeptide of claim 4 in a sample comprising:

a) contacting the sample with a compound which selectively binds to the polypeptide; and

b) determining whether the compound binds to the polypeptide in the sample to thereby detect the presence of a polypeptide of claim 4 in the sample.

8. A kit comprising a compound which selectively binds to the polypeptide of claim 4.