Blood analyte monitoring through subcutaneous measurement
First Claim
1. A method for determining analyte concentration in blood, comprising:
- determining a subcutaneous analyte concentration from a subcutaneous region using a sensing device;
determining an analyte concentration in blood from the subcutaneous analyte concentration based on mass transfer of the analyte from blood to the subcutaneous region and on uptake of the analyte by subcutaneous cells surrounding the sensing region.
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Abstract
A method for obtaining an estimate of an analyte concentration in a first fluid from an analyte concentration in a second fluid is disclosed. The method includes obtaining measurements of an analyte concentration in a second fluid by using a sensing device. The analyte concentration estimate in the first fluid is determined from these measurements. Also disclosed is a sensing device for obtaining the measurements of an analyte concentration in the first fluid and a processor configured and arranged to determine the analyte concentration in the first body fluid according to this method. This method and device can be used, for example, to determine blood glucose concentration from measurements of the glucose concentration in subcutaneous tissue. These measurements may be made using in vitro or in vivo samples. In some instances, a subcutaneously implanted sensing device, such as electrochemical sensor, is used to make the measurements.
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Citations
37 Claims
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1. A method for determining analyte concentration in blood, comprising:
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determining a subcutaneous analyte concentration from a subcutaneous region using a sensing device;
determining an analyte concentration in blood from the subcutaneous analyte concentration based on mass transfer of the analyte from blood to the subcutaneous region and on uptake of the analyte by subcutaneous cells surrounding the sensing region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An analyte measurement system comprising:
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a sensing device; and
a processor coupled to the sensing device and configured and arranged to determine an analyte level in blood, from signals generated by the sensing device, based on mass transfer of the analyte from blood to a subcutaneous region and on uptake of the analyte by subcutaneous cells surrounding the subcutaneous region. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. An apparatus for determining analyte concentration in blood based on measurements of analyte concentration determined using a sensing device, comprising:
a processor configured and arranged to determine analyte concentration in the blood from a measured subcutaneous analyte concentration based on mass transfer of the analyte from blood to a subcutaneous region and on uptake of the analyte by subcutaneous cells surrounding the subcutaneous region. - View Dependent Claims (26)
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27. A method for determining analyte-concentration in a first body fluid, comprising:
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obtaining measurements of an analyte concentration in a second body fluid, different from the first body fluid, from a sensing device; and
determining an analyte concentration estimate in the first fluid from the measurements by minimizing the relation;
f[b]=χ
2[b]+λ
Ψ
[b],wherein b is a vector representing analyte concentration in the first body fluid, χ
2[b] is a function representing a fit between the estimates and the measurements, λ
is a weighting function, and Ψ
[b] is a function indicating smoothness of the analyte concentration estimates in the first body fluid. - View Dependent Claims (28, 29, 30, 31, 32, 33)
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34. An analyte measurement system, comprising:
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a sensing device; and
a processor, coupled to the sensing device, that is configured and arranged to determine an analyte concentration estimate in a first fluid from measurements of analyte concentration in a second body fluid by minimizing the relation;
f[b]=χ
2[b]+Ψ
[b],wherein b is a vector representing analyte concentration in the first body fluid, χ
2[b] is a function representing a fit between the estimates and the measurements, λ
is a weighting function, and Ψ
[b] is a function indicating smoothness of the analyte concentration estimates in the first body fluid. - View Dependent Claims (35, 36, 37)
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Specification