Analyte measuring biosensor chip using image scanning system
First Claim
1. A biosensor system comprising:
- an implantable analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted; and
scanning means configured to quantiflably detect changes in the displacement volume of the hydrogel slab when it is implanted within the body.
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Accused Products
Abstract
An implantable chip biosensor for detecting an analyte in vivo in body fluids comprises an analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte, such as glucose, in a patient'"'"'s body fluid, the slab being disposed in a groove in a support block. The biosensor chip is ‘read’ by an external scanner configured to quantifiably detect changes in the displacement volume of the hydrogel slab. The support block is made of rigid or semi-rigid support material to restrain expansion of the hydrogel in all but one dimension, and the groove has one or more openings covered with a semipermeable membrane to allow contact between the patient'"'"'s body fluid and the hydrogel. The scanning means may be any type of imaging devices such as an ultrasound scanner, a magnetic resonance imager (MRI), or a computerized tomographic scanner (CT) capable of resolving changes in the slab'"'"'s dimensions.
152 Citations
71 Claims
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1. A biosensor system comprising:
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an implantable analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a body fluid in a body in which the hydrogel slab is implanted; and
scanning means configured to quantiflably detect changes in the displacement volume of the hydrogel slab when it is implanted within the body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. An implantable biosensor chip for implantation into a patient'"'"'s body comprising:
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a support block formed of rigid or semi-rigid, biocompatible material, a groove in the support block having one or more openings permitting penetration of a patient'"'"'s body fluid, and an analyte sensitive hydrogel slab disposed within the groove, said hydrogel slab being chemically configured to vary its displacement volume according to changes in concentration of an analyte in the body fluid, and said hydrogel slab being further configured to be detectable by externally-based means for imaging body structures. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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63. A biosensor system comprising:
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an implantable sensor chip including an analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte in a patient'"'"'s body fluid; and
image scanning means configured to image the hydrogel slab and to quantify changes in the displacement volume. - View Dependent Claims (64, 65, 66, 67, 68, 69, 70, 71)
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Specification