Brain signal feedback for pain management

• US 20030100931A1
• Filed: 04/26/2002
• Published: 05/29/2003
• Est. Priority Date: 11/28/2001
• Status: Abandoned Application

• Current Assignee: Keith Mullett
• Original Assignee: Keith Mullett
• Inventors: Mullett, Keith
• Application Number:
  US10/132,508
• Publication Number:
  US 20030100931A1
• Time in Patent Office: Days
• US Class Current: 607/46
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/36071 Pain

Abstract

System and method for pain management therapy that provides customized signal analysis for each patient'"'"'s perception of pain. In addition, the pain relief response to the sensed brain wave signals indicating perceived pain can also be customized for each patient. An implantable medical device system senses and analyzes a brain wave signal for an indication of pain. Feedback control for providing pain management therapy with the implantable medical device system is provided based on the indication of pain from the analysis of the brain wave signal. The brain wave signal can continue to be sensed and analyzed to determine whether the pain management therapy is effective in reducing or eliminating the indication of pain in the brain wave signal. Based on the analysis, parameters used to control the amount of pain management therapy and/or the type of pain management therapy can be adjusted.

Claims

1. An implantable medical device system comprising:

a first lead, comprising a first electrode; and

an implantable signal analyzing unit, wherein the first electrode is operatively coupled to the implantable signal analyzing unit, the implantable signal analyzing unit comprising;

an electrical power supply;

a signal analyzer coupled to the electrical power supply, wherein the signal analyzer is operable to receive a brain wave signal through the first electrode and is operable to analyze the brain wave signal to determine the presence of a signal form associated with pain; and

a pain management response unit operatively coupled to the signal analyzer, where the pain management response unit is operable to provide therapy for pain management in response to the signal form associated with pain.

2. The implantable medical device system of claim 1, wherein the pain management response unit comprises a pulse generator operatively coupled to the first electrode, the pulse generator capable of delivering a series of electrical pulses through the first electrode.

3. The implantable medical device system of claim 2, wherein the pulse generator comprises a frequency range selector.

4. The implantable medical device system of claim 2, wherein the pulse generator comprises a voltage range selector.

5. The implantable medical device system of claim 1, wherein the first lead further comprises a second electrode, a third electrode and a fourth electrode, wherein the first electrode, the second electrode, the third electrode, and the fourth electrode are operatively coupled to the implantable signal analyzing unit.

6. The implantable medical device system of claim 5, wherein the signal analyzer is operable to receive the brain wave signal through the first electrode and one or more of the second electrode, the third electrode, and the fourth electrode.

7. The implantable medical device system of claim 5, wherein the therapy for pain management provided by the pain management response unit includes a series of electrical pulses delivered through one or more of the first electrode, second electrode, the third electrode, and the fourth electrode.

8. The implantable medical device system of claim 1, the system further comprising a second lead that comprises a stimulation electrode, wherein the stimulation electrode is operatively coupled to the pain management response unit, whereby the pain management response unit is capable of delivering a series electrical pulses through the stimulation electrode.

9. The implantable medical device system of claim 8, wherein the pain management response unit comprises a pulse generator, whereby the pain management response unit is capable of delivering a series of electrical pulses through the first electrode and the stimulation electrode.

10. The implantable medical device system of claim 1, wherein the pain management response unit comprises a drug infusion catheter operatively coupled to an electronic drug infusion pump system, the electronic drug infusion pump system operatively coupled to the pain management response unit, whereby the pain management response unit is capable of activating the electronic drug infusion pump system to provide a drug through the drug infusion catheter for the therapy for pain management.

11. The implantable medical device system of claim 10, wherein the pain management response unit comprises a pulse generator capable of providing a series electrical pulses through the first electrode as a part of the therapy for pain management.

12. The implantable medical device system of claim 10, wherein the first lead further comprises a second electrode, a third electrode, and a fourth electrode operatively coupled to the implantable signal analyzing unit, wherein the signal analyzer is operable to receive the brain wave signal through one or more of the first electrode, second electrode, the third electrode, and the fourth electrode, and wherein the pain management response unit is capable of delivering a series electrical pulses through one or more of the first electrode, second electrode, the third electrode, and the fourth electrode for the pain management therapy.

13. The implantable medical device system of claim 1, wherein the signal analyzer is capable of analyzing the brain wave signal during the therapy for pain management for the presence of the signal form associated with pain.

14. The implantable medical device system of claim 1, wherein the pain management response unit comprises a timer capable of timing delivery of therapy for pain management for a predetermined time interval after the signal analyzer determines the presence of the signal form associated with pain.

15. The implantable medical device system of claim 14, wherein the pain management response unit is operable to modify the therapy for pain management when the timer expires and the signal analyzer is operable to determine a continued presence of the signal form associated with pain.

16. The implantable medical device system of claim 15, wherein the pain management response unit is operable to utilize a hierarchy of modifications to the therapy for pain management when the timer expires and the signal analyzer is operable to determine the continued presence of the signal form associated with pain.

17. An implantable signal analyzing unit, comprising:

an electrical power supply;

a signal analyzer coupled to the electrical power supply, wherein the signal analyzer is operable to receive a brain wave signal and is operable to analyze the brain wave signal to determine the presence of a signal form associated with pain; and

a pain management response unit operatively couple to the signal analyzer, where the pain management response unit is operable to provide therapy for pain management in response to the signal form associated with pain.

18. The implantable signal analyzing unit of claim 17, wherein the pain management response unit comprises a pulse generator capable of generating a series of electrical pulses for the therapy for pain management.

19. The implantable signal analyzing unit of claim 18, wherein the pulse generator comprises a frequency range selector.

20. The implantable signal analyzing unit of claim 18, wherein the pulse generator comprises a voltage range selector.

21. The implantable signal analyzing unit of claim 17, wherein the pain management response unit comprises an electronic drug infusion pump that is capable of providing a drug for the therapy for pain management.

22. The implantable signal analyzing unit of claim 21, wherein the pain management response unit comprises a pulse generator capable of generating a series of electrical pulses for the therapy for pain management.

23. The implantable signal analyzing unit of claim 17, wherein the signal analyzer is capable of analyzing the brain wave signal during the therapy for pain management for the presence of the signal form associated with pain.

24. The implantable signal analyzing unit of claim 17, wherein the pain management response unit comprises a timer capable of timing delivery of therapy for pain management for a predetermined time interval after the signal analyzer determines the presence of the signal form associated with pain.

25. The implantable signal analyzing unit of claim 24, wherein the pain management response unit is operable to modify the therapy for pain management when the timer expires and the signal analyzer is operable to determine a continued presence of the signal form associated with pain.

26. The implantable signal analyzing unit of claim 25, wherein the pain management response unit is operable to utilize a hierarchy of modifications to the therapy for pain management when the timer expires and the signal analyzer is operable to determine the continued presence of the signal form associated with pain.

27. A method of managing pain, comprising:

sensing a brain wave signal within a brain with an implantable medical device system;

analyzing the brain wave signal for an indication of pain with the implantable medical device system; and

providing pain management therapy with the implantable medical device system based on the indication of pain from the analysis of the brain wave signal.

28. The method of claim 27, comprising positioning a first electrode in a sensory thalamus region of a brain, and sensing the brain wave signal through the first electrode of the implantable medical device system.

29. The method of claim 28, wherein providing pain management therapy comprises delivering electrical stimulation pulses having a frequency in a selected frequency range to the sensory thalamus region of the brain with the implantable medical device system.

30. The method of claim 29, wherein providing pain management therapy comprises delivering electrical stimulation pulses in a selected voltage range with the implantable medical device system.

31. The method of claim 29, wherein providing pain management therapy comprises delivering electrical stimulation pulses having the frequency in the selected frequency range to both the sensory thalamus region and the periventricular gray region of the brain with the implantable medical device system.

32. The method of claim 28, wherein providing pain management therapy comprises delivering electrical stimulation pulses having a frequency in a selected frequency range to a periventricular gray region of the brain with the implantable medical device system.

33. The method of claim 28, wherein providing pain management therapy comprises delivering a drug to a body with the implantable medical device system.

34. The method of claim 33, wherein delivering the drug comprises delivering the drug directly to the sensory thalamus region of the brain with the implantable medical device system.

35. The method of claim 33, wherein delivering the drug comprises delivering the drug directly to a periventricular gray region of the brain with the implantable medical device system.

36. The method of claim 33, wherein providing pain management therapy comprises delivering electrical stimulation pulses having a frequency in a selected frequency range to the sensory thalamus region of the brain with the implantable medical device system.

37. The method of claim 33, wherein providing pain management therapy comprises delivering electrical stimulation pulses having a frequency in a selected frequency range to a periventricular gray region of the brain with the implantable medical device system.

38. The method of claim 33, wherein providing pain management therapy comprises delivering electrical stimulation pulses having the frequency in the selected frequency range to both the sensory thalamus region and a periventricular gray region of the brain with the implantable medical device system.

39. The method of claim 27, wherein providing pain management therapy comprises analyzing the brain wave signal during pain management therapy with the implantable medical device system for the brain wave signal that provides the indication of pain.

40. The method of claim 27, comprising timing the pain management therapy provided with the implantable medical device for a predetermined time interval after the indication for the indication of pain.

41. The method of claim 40, comprising modifying the pain management therapy provided with the implantable medical device when the predetermined time interval expires and the analysis of the brain wave signal indicates pain.

42. The method of claim 41, wherein modifying the pain management therapy provided with the implantable medical device comprises utilizing a hierarchy of modifications to the therapy for pain management when the time interval expires and the analysis of the brain wave signal indicates pain.