Compliant tissue sealants
First Claim
1. A compliant polymeric material on a tissue surface, wherein the material is formed by the polymerization of an aqueous solution or suspension of a polymerizable monomer in contact with the tissue surface, and wherein the normalized compliance ratio of the tissue and the material is in the range of about 0.05 to about 3.
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Accused Products
Abstract
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
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Citations
23 Claims
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1. A compliant polymeric material on a tissue surface, wherein the material is formed by the polymerization of an aqueous solution or suspension of a polymerizable monomer in contact with the tissue surface, and
wherein the normalized compliance ratio of the tissue and the material is in the range of about 0.05 to about 3.
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12. A method for forming a compliant polymeric material on a tissue surface, the method comprising
applying an aqueous solution or suspension of a polymerizable monomer to the surface; - and
polymerizing the material on the surface;
wherein the normalized compliance ratio of the tissue and the material is in the range of about 0.05 to about 3. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification