Pharmaceutical dosage forms for highly hydrophilic materials
First Claim
1. A pharmaceutical dosage form comprising:
- a fill material including a carrier of at least about 40% w/w of a hydrophilic surfactant, and at least one pharmaceutically active agent; and
a shell encapsulating the fill material, said shell containing at least one plasticizing agent in an amount sufficient to maintain an effective shell plasticity upon migration of a portion of the plasticizing agent into the fill material.
2 Assignments
0 Petitions
Accused Products
Abstract
Pharmaceutical dosage forms having a highly hydrophilic fill material and a shell encapsulating the fill material are disclosed and described. Generally, the shell has at least one plasticizing agent therein in order to provide the shell with an effective plasticity. In one aspect, the shell may have included therein an amount of plasticizing agent that is sufficient to provide the shell with an effective plasticity upon migration of a portion of the plasticizing agent into the fill material. In another aspect, the plasticizing agent may have a solubility in the fill material of less than about 10% w/w. In yet another aspect, a combination of a plasticizing agent, and a plasticizing agent having a solubility in the fill material of less than about 10% w/w, may be presented in a total amount sufficient to provide the shell with an effective plasticity upon migration of plasticizing agent into the fill material.
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Citations
37 Claims
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1. A pharmaceutical dosage form comprising:
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a fill material including a carrier of at least about 40% w/w of a hydrophilic surfactant, and at least one pharmaceutically active agent; and
a shell encapsulating the fill material, said shell containing at least one plasticizing agent in an amount sufficient to maintain an effective shell plasticity upon migration of a portion of the plasticizing agent into the fill material. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 32, 33, 34, 35, 36)
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2. A pharmaceutical dosage form comprising:
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a fill material including a carrier of at least about 40% w/w of a hydrophilic surfactant, and at least one pharmaceutically active agent; and
a shell encapsulating the fill material, said shell containing an effective amount of a plasticizing agent having a solubility of less than 10% w/w in the fill material. - View Dependent Claims (30, 31)
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37. A pharmaceutical dosage form comprising:
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a fill material including a carrier of at least about 40% w/w of a hydrophilic surfactant, and at least one pharmaceutically active agent; and
a shell encapsulating the fill material, said shell containing a first plasticizing agent and a second plasticizing agent, said second plasticizing agent having a solubility in the fill material of less than about 10% w/w agent, wherein the first and second plasticizing agents are present in amounts sufficient to maintain an effective shell plasticity upon migration of a portion of either plasticizing agent into the fill material.
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Specification