Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same
First Claim
1. A method of enhancing fluid flow through a vascular site occupied by a vascular occlusion, said method comprising:
- simultaneously flushing said vascular site with;
(i) a dissolution fluid; and
(ii) a dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid;
whereby fluid flow is enhanced through said vascular site.
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0 Petitions
Accused Products
Abstract
Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e.g., an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Examples of dissolution fluid/dissolution fluid attenuating fluid pairs include: (1) oxidizing agent fluid and fluid comprising oxidizable neutralizing agent; (2) surfactant fluid and phosphate buffered saline; (3) acidic solution and phosphate buffered saline; etc. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.
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Citations
51 Claims
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1. A method of enhancing fluid flow through a vascular site occupied by a vascular occlusion, said method comprising:
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simultaneously flushing said vascular site with;
(i) a dissolution fluid; and
(ii) a dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid;
whereby fluid flow is enhanced through said vascular site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 41, 42, 43, 44)
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14. A method of enhancing fluid flow through a vascular site occupied by an organic matter comprising vascular occlusion, said method comprising:
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simultaneously flushing said vascular site with;
(i) an organic matter dissolution fluid; and
(ii) an organic matter dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said organic matter comprising vascular occlusion is contacted with non-attenuated organic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated organic matter dissolution fluid;
whereby fluid flow is enhanced through said vascular site. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A method of enhancing fluid flow through a vascular site occupied by an inorganic matter comprising vascular occlusion, said method comprising:
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simultaneously flushing said vascular site with;
(i) an inorganic matter dissolution fluid; and
(ii) an inorganic matter dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated inorganic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated inorganic matter dissolution fluid;
whereby fluid flow is enhanced through said vascular site. - View Dependent Claims (23, 24, 25, 26, 27)
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28. A method of enhancing fluid flow through a vascular site occupied by vascular occlusion, said method comprising:
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simultaneously flushing said vascular site with;
(i) a dissolution fluid that dissolves both organic and inorganic matter; and
(ii) a dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid;
whereby fluid flow is enhanced through said vascular site. - View Dependent Claims (29, 30, 31, 32, 33)
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34. A system for use in enhancing fluid flow through a vascular site occupied by an vascular occlusion, said system comprising:
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a means for simultaneously flushing said vascular site with a dissolution fluid and a dissolution fluid attenuating fluid;
a dissolution fluid; and
an dissolution fluid attenuating fluid. - View Dependent Claims (35, 36, 37, 38, 39, 40)
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45. A lesion dissolution fluid comprising:
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an acid; and
a surfactant. - View Dependent Claims (46, 47, 48, 49, 50, 51)
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Specification