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ENHANCING THE CIRCULATING HALF LIFE OF ANTIBODY-BASED FUSION PROTEINS

  • US 20030105294A1
  • Filed: 02/24/1999
  • Published: 06/05/2003
  • Est. Priority Date: 02/25/1998
  • Status: Abandoned Application
First Claim
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1. An antibody-based fusion protein with an enhanced circulating half-life, comprising at least a portion of an immunoglobulin (Ig) heavy chain having substantially reduced binding affinity for an Fc receptor, said portion of heavy chain being linked to a second non-Ig protein, said antibody-based fusion protein having a longer circulating half-life in vivo than an unlinked second non-Ig protein.

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