Method and composition for removing uremic toxins in dialysis processes
First Claim
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1. A device for removing uremic toxins in a dialysis procedure comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon; and
the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease or the zirconium oxide layer.
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Abstract
Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.
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Citations
58 Claims
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1. A device for removing uremic toxins in a dialysis procedure comprising:
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a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon; and
the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease or the zirconium oxide layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A cartridge for use in a dialysis system for removing toxins comprising:
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a body having an inlet end and an outlet end;
an interior including at least four layers, the layers including a first layer of a resin selected from the group consisting of zirconium phosphate having a pH of approximately 2.5 to about 5 and urease, a second layer of a resin selected from the group consisting of zirconium oxide having a pH of approximately 9 to about 13 and urease, a third layer of zirconium phosphate, and a fourth layer of zirconium oxide having a pH of approximately 6.5 to about 7.5; and
the interior being so constructed and arranged that a fluid entering the interior from the first inlet end flows through the first layer, then the second layer, then the third layer, and then the fourth layer. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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19. A device for regenerating a dialysis solution comprising:
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a body including a resin bed; and
the resin bed including at least a layer of urease, zirconium phosphate, zirconium oxide, and carbon and being so constructed and arranged that a dialysis solution having a pH that is either basic or acidic will exit the cartridge after it passes through the resin bed at a pH of approximately 7 to about 7.8. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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28. A device for use in a system for treating a patient with a dialysis solution comprising:
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an inlet in fluid communication with a source of dialysis solution;
a body including the inlet and defining an interior and having an outlet;
the body comprising a resin bed comprising a layer of urease, a layer of zirconium oxide, and a layer of zirconium phosphate that define a three layer structure; and
the resin bed being oriented so that the first layer that the dialysis solution contacts of the three layer structure is either the urease or the zirconium phosphate layer and the zirconium oxide layer is so constructed and arranged that a basic or an acidic dialysis solution entering the inlet will exit the outlet with a physiologically acceptable pH. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36)
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- 37. A method for constructing a cartridge for use in a system for providing dialysis comprising the steps of providing a resin bed including zirconium oxide and zirconium phosphate and selecting and orienting the layers of zirconium oxide and zirconium phosphate to allow the resin bed to remove uremic toxins present in a dialysis solution entering the resin bed and causing a dialysis solution exiting the cartridge to have a physiological pH and include a physiological acceptable electrolyte balance.
- 46. A method for providing dialysis comprising the steps of passing a dialysis fluid through a body having an inlet and an outlet and defining an interior, the interior including at least four layers, a first layer comprising zirconium phosphate having a pH of approximately 2.5 to about 5 or urease, a second layer comprising zirconium oxide having a pH of approximately 9 to about 13 or urease, a third layer comprising zirconium phosphate and a fourth layer comprising zirconium oxide having a pH of approximately 6.8 to about 7.5.
- 55. A method of providing regenerative dialysis comprising the step of removing at least some uremic toxins by passing a dialysis fluid through a body having an inlet and an outlet and defining an interior, the interior including at least four layers, a first layer comprising zirconium phosphate having a pH of approximately 2.5 to about 5 or urease, a second layer comprising zirconium oxide having a pH of approximately 9 to about 13 or urease, a third layer comprising zirconium phosphate and a fourth layer comprising zirconium oxide having a pH of approximately 6.8 to about 7.5.
Specification