Biodegradable drug delivery material for stent

• US 20030105518A1
• Filed: 01/10/2003
• Published: 06/05/2003
• Est. Priority Date: 04/13/2000
• Status: Active Grant

• Current Assignee: Debashis Dutta
• Original Assignee: Debashis Dutta
• Inventors: Dutta, Debashis
• Granted Patent: US 7,390,333 B2
• Time in Patent Office: Days
• US Class Current: 623/1.38
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

A stent is fabricated utilizing a polymer that is selected for its tendency to degrade from the surface inwardly rather than undergo bulk erosion so as to substantially reduce the risk of large particles becoming detached and being swept downstream. Such polymer is hydrophobic yet has water-labile linkages interconnecting the monomers. Ester or imide bonds are incorporated in the polymer to render the surface degrading materials suitable for use in stent applications. The stent may be coated with such polymer or may be wholly formed therefrom.

Claims

1. A stent wholly constructed of a biodegradeable polymer that degrades from its surface inwardly when subjected to blood flow, such that bulk erosion is effectively precluded.

2. The stent of claim 1, wherein said polymer is hydrophobic and has water-labile linkages connecting monomers.

3. The stent of claim 2, wherein said polymer comprises a polyanhydride.

4. The stent of claim 3, wherein said polymer incorporates ester bonds.

5. The stent of claim 3, wherein said polymer incorporates imide bonds.

6. The stent of claim 2, wherein said polymer comprises a polyorthoester.

7. The stent of claim 6, wherein said polymer incorporates ester bonds.

8. The stent of claim 6, wherein said polymer incorporates imide bonds.

9. The stent of claim 1, wherein said polymer is loaded with a pharmacological agent.

10. The stent of claim 9, wherein said pharmaceutical agent comprises heparin.

11. A coated stent, comprising:

an underlying structure of metallic material;

a coating of biodegradable polymer that degrades from its surface inwardly when subjected to blood flow, such that bulk erosion is effectively precluded.

12. The coated stent of claim 11, wherein said polymer comprises a polyanhydride.

13. The coated stent of claim 12, wherein said polymer incorporates ester bonds.

14. The coated stent of claim 12, wherein said polymer incorporates imide bonds.

15. The coated stent of claim 11, wherein said polymer comprises a polyorthoester.

16. The coated stent of claim 15, wherein said polymer incorporates ester bonds.

17. The coated stent of claim 15, wherein said polymer incorporates imide bonds.

18. The coated stent of claim 11, wherein said polymer is loaded with a pharmacological agent.

19. The coated stent of claim 18, wherein said pharmacological agent comprises heparin.